exam 3 integument 1 Flashcards
Palpable elevation filled with clear fluid – Vesicle < 1cm – Bulla > 1cm • Causes – Auto-immune dermatoses – Viral infections – Chemical irritants – Burns
Vesicle/Bulla
lead to formation of vesicle/bulla…
Palpable elevation filled with pus • Cause – leukocyte infiltrate
pustule
Dried exudate, serum, blood, and scale that is adhered to the skin surface • Causes – Severe disorders of keratinization – Severe pustular dermatitis – Secondary to ulcers
crust
solid, elevated mass < 1cm diameter • Causes – Infiltrate of inflammatory cells – Infiltrate of neoplastic cells – Epidermal hyperplasia – Deposit of mineral
papule
>1cm diameter and deeper
nodule
coalesced papules
Plaques
plaque
nodule
Loss of epidermis with exposure of dermis • Cause: 2ndary to… – Epidermal necrosis – Inflammation – Infarction – Neoplasia
ulcer
Accumulation of loose keratinized cells • Causes – Disorders of keratinization – Chronic dermatitis
scale
a circular rim of scale that occurs secondary to rupture of a vesicle, pustule, or papule
Epidermal collarette –
Thickening and hardening of the skin • Causes – Chronic irritation/inflammation
Lichenification
inflam
What should u do for biopsy
What should u not do with collecting biopsy
St Johns Wort
photosensitization because on ly on white fur
Solar injury
“solar/actinic keratosis”
This squamous cell carcinoma can be a result of ___
solar injury from years before
1 st degree – epidermis – Reddened/darkened necrotic epidermis – Complete healing • 2 nd degree – epidermis and dermis – Vesicle formation – Some adnexa are preserved allowing epidermal regeneration with some scarring • 3rd degree – full thickness epidermis and dermis +/- subcutis – Sloughing of necrotic tissue, followed by granulation tissue – Scar; life threatening (fluid/protein loss and portal for sepsis)
thermal burns
what degree?
3
Caused by body or wound secretions, application of drugs, exposure to acids, alkalies, soaps, detergents, or irritant plants. Chem burn in st kitts on the backs of animals after it rains from toxins in the
Manchineel tree
Pathogenesis thought to involve type IV hypersensitivity towards antigens of the surface of keratinocytes inducing apoptosis – induced via antigenic mimicry from drug administration, underlying infection, neoplasia, dyes/preservatives in pet foods? – Histologically distinct – Gross: Widespread coalescing erythematous macules vesicles and ulcers
Erythema Multiforme & Toxic Epidermal Necrolysis
