Exam 3 - 14-16 Flashcards
What are transient microbiota
Stays in a region for variable amount of time
What are normal microbiota
Specific to a certain region of the body and nonpathogenic
What are microbial antagonism
Normal microbiota inhibiting growth of pathogenic microbiota
What is symbiosis
Relationship between micro organisms
What is commensalism
Host benefits but parasite is unaffected
What is mutualism
Both host and parasite mutually benefit
What is parasitism
Parasite benefits and host is affected
What is an opportunistic pathogen
A normal micro organism becoming pathogenic
What is the syndrome
Signs and symptoms
What is Koch’s postulates
Inoculate disease from dead animal. Culture plus microscope to identify. Inject lab animal with pure culture. Culture new animals disease plus microscope to identify.
If they match then you found a disease.
What are signs
What you see you
What are symptoms
What you feel
What is a communicable disease
Spreads from one organism to another
What is a contagious disease
Easily spreads from one organism to another
What is a non-communicable disease
Doesn’t always cause disease or symptoms. Not from people i.e. doorknob
What is a sporadic disease
And outbreak that pops up occasionally
What is an endemic disease
Disease that is constantly present in an environment
What is an epidemic disease
Widespread disease in a given area
What is a pandemic disease
Widespread disease around the world
What does acute mean
Short and sudden
What does chronic mean
Slow and long
What does sub acute mean
Between acute and chronic. Intermediate
What does latent mean
Disease that is dormant and arises suddenly due to stress in the body
What is incidence
Number of people with the disease in a given area at a given time
What is prevalence
Percent chance of infection in any given population
What is herd immunity
When few animals are vaccinated the rest end up becoming immune due to low incidence
What is local infection
In a limited area of the body
What is systemic infection
The whole body is affected
What is focal infection
Started in one area but moves to another
What is sepsis
Information from the spread of microbes that may or may not be toxic
What is bacteremia
Bacteria in the blood
What is toxemia
Toxins in the blood
What is virusemia
Viruses in the blood
What is the primary infection
The first infection you
What is secondary infection
Secondary infection that occurs due to immunocompromised health
What are the four predisposing factors for disease
Temperature, age, stress, lifestyle
What is a subclinical infection
And asymptomatic infection. The carrier
What are the five stages of disease and describe each one
Incubation period: asymptomatic. Prodromal.: Mild symptoms.
Period of illness: very sick.
Period of decline: almost not sick. Period of convalescence: not sick anymore.
What is a reservoir
A source of an infection
What is a carrier
Infected individual but asymptomatic
What is a vector
The source of infection i.e. fleas
What is a zoonosis
Disease transmissible from animal to human and vice versa
What is a nonliving reservoir
I.e. soil
What is contact transmission
When one animals body fluids are going into another mucous membrane
What is indirect transmission
Nonliving reservoir
What is a fomite
I.e. doorknob
What is droplet transmission
Spread by droplets
What is waterborne transmission
Carried by water
What is airborne transmission
Carried by air
What is mechanical transmission
Transmission by touching IE fly
What is biological transmission
Blood touching infected blood IE mosquito
What is nosocomical
Disease coming from a clinic
What is a compromise host
A host that has a change in homeostasis
What is epidemiology
Study of disease transmission
What is morbidity
The incidence of disease. To which extent the disease affects you
What is mortality.
The incidence of death from a disease
What is Virulence
Degree of pathogenicity
What are the portals of transmission
Skin, mucous membranes, umbilical cord
What is the preferred portal of entry
Specific to bacteria. If it is not the preferred portal and it will not make you sick
What is id50
Quantity of bacteria that gets you sick.
What is LD50
Amount of bacteria that is required to be the lethal dose for 50% of host cells
What is adherence
Organisms that attach to host
What are adhesians
Ligans. Molecule in host that allows attachment of bacteria
What is a biofilm
Produce a sticky substance that increases adherence
What do bacteria do to affect penetration
Capsule, cell wall components Enzymes Antigenic variation Cytoskeleton penetration
What is an M protein
Resistant to host defences
What are coagulases
Break down components of clots
What are kinases
Breakdown components of clots
What are hyaluronidase
Break down connective tissue
What is iga protease
Beaks down antibodies
What is antigenic variation
When bacteria change proteins on their surface
What do invasions do
Affect cytoskeleton of cells
What do siderophores do
Steal host iron
What does direct damage to host cells
Multiplication inside of them until they rupture
What is an endotoxins from
Part of microbe
What is an exotoxins
Released by bacteria
What is innate immunity
Nonspecific, born with it
What is adaptive immunity
Specific. Acquired
What is the first line of defense
How it gets in. Nonspecific physical and chemical surface barriers
What is the second line of defense
Nonspecific intercellular and chemical defense
What is the third line of defense
Immune response
What is chemo taxis
Moving towards chemicals
What are toll like receptors
Receptors found on the cells of a host
What is PAMP
Molecules on Invadir that allows body to recognize that it’s foreign
What are the surface barriers
Skin, mucous membranes
What are the internal defense
Phagocytes, natural killer cells, inflammation, antimicrobial proteins, fever
What is humoral immunity
B cells
What is cellular immunity
T cells
What is the ciliary elevator
Cilia moves mucus up the respiratory tract
What is the normal microbiota
Having normal microbiota inhibits growth of abnormal microbiota
What are the three granulocytes
Neutrophils, eosinophils, basophils
What are the three agranulocyte’s
Lymphocytes, monocytes, Dendridic cells
What is the function of the lymphatic system
Drain fluid from tissues
What are the four stages of inflammation
Tissue damage,
vasodilation,
phagocytosis,
tissue repair
What is diapedesis
Movement of leukocytes out of the capillories between epithelial cells
What effect does vasodilation have on the body
Increased blood flow, increased metabolic rate
What is kinins
Chemicals that cause vasodilation and increased permeability
Where are prostaglandins released by and what are they do
Damage to cells, help Phagocytes movement
What do leukotrienes do
Help blood get anti-inflammatories
What is the purpose of the fever
Macro phages secrete pyrogens which cause the liver and spleen to give up iron and zinc which is necessary for growth
What is opsonization
The coating of a pathogen to enhance phagocytosis
What is inflammation
Triggers vasodilation and chemo taxis
What is Cytolysis
Injection into pathogen cell membrane (MAC molecule) that creates pores
What do interferons do
Proteins released by the virus-infected cells which prevent viral replication in other host cells
What do you iron binding proteins do and which are they
Find iron so bacteria cannot have it. Transferon, lactoferon, feratin, hemoglobin