Exam 2- Chapter 7

Question 1

How is T cell development similar to B cell development?

Answer 1

They undergo rearrangement and have positive and negative feedback

Question 2

T cells originate in the:

They mature in the:

Answer 2

Bone marrow

Thymus

Question 3

Co-receptors for T cells

Answer 3

CD4 and CD8

Question 4

Mature T cells leave the thymus and travel to:

Answer 4

Second lymphoid tissues

Question 5

Lymphoid organ in the thorax above the heart

Answer 5

Thymus

Question 6

Thymocytes as part of thymic stroma

Answer 6

Immature T cells

Question 7

2 parts of a thymus

Answer 7

Cortex

And medulla

Question 8

What happens to T cells in the thymus?

Answer 8

Maturation- no lymphocyte recirculating

Question 9

When does the thymus start to degenerate?

Answer 9

Thymus?

Question 10

How do T cell progenitors differ from mature T cells?

Answer 10

They have different markers

Question 11

What happens with progenitors interact with stromal cells?

Answer 11

They divide and differentiate

Question 12

Double negative thymocytes have no expression of:

Answer 12

CD4 or CD8

Question 13

What 2 things assist with T cell development?

Answer 13

Interleukin- 7 (IL-7) and Notch

Question 14

IL-7 is secreted by:

Answer 14

Stromal cells

Question 15

Contact points of T cells

Answer 15

IL-7 and Notch

Question 16

Double negative lymphocytes make what receptors?

Answer 16

Alpha beta lymphocytes

Question 17

Which gene receptor dominates receptor production

Answer 17

The receptor with the genes rearranged the fastest

Question 18

Double-positive thymocytes use what receptors

Answer 18

CD4 and CD8

Question 19

What happens to T cells that do not arrange correctly

Answer 19

They die by apoptosis

Question 20

A common double negative T cell progenitor gives rise to:

Answer 20

Alpha:beta and gamma:delta T cells

Question 21

Pre-T-cell receptors have what chains? With what complex?

Answer 21

Beta chain and a surrogate alpha-chain with the CD3 complex

Question 22

Where is alpha chain checked for compatibility with the beta chain?

Answer 22

In the ER

Question 23

Two different T cell receptors coming together:

Answer 23

Superdimer

Question 24

First phase of T cell development

Answer 24

Produce productive TCRs

Question 25

Second phase of T cell development (2)

Answer 25

Ensure that the TCR can recognize the MHC molecules

Elimination of self-reactive T cells

Question 26

Positive selection for T cells

Answer 26

Recognize self-MHC

Question 27

Percentage of the double-positive thymocytes that continue through positive selection

Answer 27

Only 2%.

Question 28

Where does positive selection for T cells take place

Answer 28

In the cortex of the thymus

Question 29

Binding between MHC and TCR allows cell to:

Answer 29

Survive and mature

Question 30

Positive selection selects cells that can”

Answer 30

Interact with MHC molecules

Also determines if a T cell will become a CD4 or CD8 T cell

Question 31

Process of thymocytes

Answer 31

Double negatives
To double positives
To single positives

Question 32

What cells do negative selection delete?

Answer 32

Cells whose antigens bind too tightly to the self-peptides and self-MHC molecules. Gets rid of auto-reactive T cells

Question 33

Negative selection is mediated by:

Answer 33

Dendritic cells and macrophages

Question 34

Auto-reactive T cells undergo

Answer 34

Apoptosis

Question 35

CD4 T cells, in addition to macrophage and B cell activation, can also be:

Answer 35

Regulatory CD4 T cells (Treg)

Question 36

What do regulatory T cells do?

Answer 36

They suppress the autoimmune response of naive T cells. They work to find and shut down any self attacking cells that may have been released.

Question 37

Mature T cells are free to:

Answer 37

Circulate through the body to encounter their specific antigens- they circulate for several years

Question 38

What is triggered after Mature T cells find their antigen

Answer 38

Division and differentiation into effector T cells

Question 39

In secondary lymphoid tissues, CD8 T cells differentiate into:

Answer 39

Cytotoxic T cells

Question 40

In secondary lymphoid tissue, CD4 T cells differentiate into

Answer 40

Helper T cells