Exam 2 Cancer Meds

Question 1

Antineoplastic agents work how?

This causes toxicity to healthy cells U located where? (4)

Answer 1

Suppress rapidly proliferating cells

Bone marrow
GI
Hair follicles
Lymph organs

Question 2

Chemo most damaging to healthy cells when?

Answer 2

During actively dividing states

Question 3

Cell Cycle-Specific Agents target what cells?

Given how?

Most effective on what kinds of CA?

Answer 3

Cells that are in the particular state the drug is meant to target

Continuously to catch cells as they move thru proliferative cycles

Hematologic
Tumors w/ large portions of cells in proliferation

Question 4

Cell Cycle-Nonspecific Agents work on what cells?

Given how?

Most effective on what kinds of Ca?

Answer 4

All cells regardless of cycle

One large dose

Low-growth, solid tumors

Question 5

Chemo more successful in tumors that are? (3)

Answer 5

1) Rapidly growing
2) Have high growth fraction (high % of cells are actively dividing)
3) Small (have more cells in growth phase)

Question 6

Large tumors harder for chemo to treat because? (4)

Answer 6

1) Penetration is difficult
2) Mets more likely
3) Resistance more likely
4) Just more cells to kill

Question 7

P-glycoprotein is?

Answer 7

Glycopro in high concentration in resistant cell membrane,

Works as efflux pump against drug

Question 8

General toxicity of Chemo agents? (6)

Answer 8

1) Bone Marrow: ↓ platelets/WBC = hemorr/infection
2) GI: N/V/D, dysphagia
3) Hair: damages follicle
4) Renal: tumor destruction ↑ nucleic acids -> ↑ uric acid -> nephrotox
5) Reproduction: tetratogenic, infertility
6) Vesicant: injection site rxn

Question 9

ABX work to tx CA how?

Answer 9

Bind DNA -> block syth or replication, cut the strand