Abuse Drugs Flashcards
Physiological dependence due to?
Neuroadaptations
Results in physical sxs/abn behavior if w/drawn
DOES NOT MEAN ADDICTION
Psychological dependence occurs w/ or w/o what?
W/draw causes?
physical dependence
dysphoria, cravings
Tolerance shifts dose-response how?
Right
Innate Tolerance is?
genetic lack of sensitivity
Pharmacokinetic Tolerance results from?
↑ metabolism
Pharmacodynamic Tolerance results from?
downreg of receptors
Learned Tolerance is?
adaptation to degree of intoxication
Conditioned Tolerance is?
familiar setting diminish effects
Acute Tolerance results from?
repeated use over short period of time
Cross Tolerance is?
one drug produces tolerance for another drug
Sensitization shifts does-response how?
Why?
Left
Responsiveness ↑↑ w/ repeated use
Addiction is?
Compulsive use to alleviate craving/dysphoria regardless of consequences
