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Q4 Pharm psych > Exam 2 Antihistamines > Flashcards

Exam 2 Antihistamines Flashcards

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1
Q

Histamine synth’d where?

A

Most tissues:
Epidermis
Gastric mucosa
Neurons in CNS

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2
Q

Histamine has what effect on brain?

A

neurotransmitter affecting arousal, endocrine, weight, temp

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3
Q

Histamine release ↑ how?

A

↑ intracellular Ca2+
IgE/antigen
Injury
Toxins/drugs

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4
Q

H1 stim results in?

A 
Release of NO -> vasodilation
Bronchospasm
Wakefulness, ↓ appetite
Efflux of proteins/fluid into ECS -> hives/edema
Itch/pain
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5
Q

H2 stim results in?

A

↑ gastric acid

Vasodilation

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6
Q

Histamine-regulated vasodilation leads to?

A

↓BP
Reflex tachy
Flushing
HA

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Q4 Pharm psych (20 decks)

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