Antipsych Flashcards
Positive sxs of schizophrenia?
Caused by?
Hallucinations (site/sound)
Delusions
Disorganized speech/thought
Over-active DA path in limbic syst (mesolimbic)
Negative sxs of schizophrenia?
Caused by?
Apathetic Withdrawn Anti-social Unmotivated Depressed
Under-active DA paths in front cortex (mesocortical)
Cognitive impairment a/w schizophrenia?
Distracted
Memory loss
Mesolimbic DA Pathway is?
Affects?
Ventral Tegmental Area (VTA) to limbic system
Emotion
Mesocortical DA Pathway is?
Affects?
VTA to front cortex
Cognition, Emotion
Nigrostriatal DA Pathway is?
Affects?
Substantia Nigra to striatum
Motor
Tuberoinfundibular DA Pathway is?
Affects?
Hypothalmus to pituitary
Prolactin
Extrapyramidial Symptoms (EPS) are?
Caused by?
Parkinson-like:
tremor, rocking, pacing, dystonia, rigidity, dyskinesia
DA Recp Antagonists blocking DA recps in nigrostriatal path ->
causes imbal of striatal DA/ACh
Treat EPS sxs how?
anticholinergics (benztropine)
Tardive Dyskinesia (TD) is?
uncontrolled mvmt of mouth/face,
from long-term tx,
U irreversible
Neuroleptic Malignant Syndrome (NMS) is?
mm rigidity, very high fever, BP/HR changes
LIFE THREATENING
NMS caused by?
DA D2 recp block in striatum and hypothalamus
NMS tx?
Dantrolene (Dantrium) DA agonist (bromocriptine)
Antipsych drug interactions:
Anticholinergics?
Sedative/Hypnotics?
TCAs?
CYP450 inducers?
Antihypertensives?
Antichol: ↑ s/e (dry mouth, constip, etc)
Sed/Hyp: ↑ sedation
TCAs: seizures, cardiac
CYP450: carbamazepine, cimetidine, smoking
Antihyp: unpredictable
Bipolar caused by?
U treated with?
Low GABAergic activity
Cobo of Li+, anticonvulsants and Zyprexa
