Exam 10: Marijuana and Stuff Flashcards
Hashish
Marijuana plant resin with super high TCH concentration
K-2 and Spice
Synthetic Marijuana
Pharmacokinetics of Marijuana
Highly lipid soluble
Accumulates in fat and is slowly released over time
High dose effects of marijuana
Paranoia, hallucinations, psychosis
Marijuana cardiovascular effects
Tachycardia
Postural hypotension
How might marijuana help with glaucoma treatment?
decrease intraocular pressure
How might marijuana help cancer patients?
Inhibition of vomiting reflex (antiemetic during chemo)
Marijuana toxicities
- Immunosuppression
- Lower testosterone
- Teratogenic
- Lung damage
Medical uses of marijuana (3)
- Prevention of nausea during chemotherapy
- Prevention of “wasting” in AIDs
- Glaucoma/asthma (data shows that it doesnt really work)
What is used in native american ceremonies to get high?
Salvia
Salvia mechanism
Salvinorin A is an agonist at kappa opioid receptors and D2 dopamine receptors
Salvia effects
Hallucinogen (different from other hallucinogens somehow)
Krakom
Plant from Thailand that is a stimulant/pain releiver
Krakom mechanism
Similar to opioids, but different…
Krakom uses
“Legal opioid”
being abused
some use it for pain control or opioid withdrawal
What neurotransmitter disturbance is seen in Alzheimer’s?
Decreased ACh in the nucleus basalts of Meynert
What drugs can be used to treat Alzheimer’s neurotransmitter disturbance?
Acetylcholinesterase inhibitors
Rivastigmine
Donepezil
How effective are acetylcholinesterase inhibitors in treating Alzheimers?
Modest improvement in cognitive function in some, not much in other.
Do not slow the progress of the disease
Side effects of donepezil, rivastigmine?
Muscarinic stuff… (leaky)
Which acetylcholinesterase inhibitor causes less side effects?
Donepezil
Memantine use
Alzheimers
Memantine mechanism
NMDA antagonist
also blocks excitatory glutamate at NDMA receptors in the hippocampus and frontal cortex
how do vitamin E, seligiline, and deprenyl help with alzheimers
antioxidant properties
controversial aka probably complete bullshit
What is the only drug that treats ALS?
Riluzole
Riluzole mechanism
inhibits excitatory glutamate
Mainstay drug of ADHD therapy
Methylphenidate
adderall
d-amphetamine/d,l-amphetamine
reserved for patients who don’t respond to methylphenidate
Adderall problem
Schedule II
can complicate prescribing
Atomoxatine mechanism
inhibits NE reuptake
Atomoxatine use
benefits ADHD patients who don’t respond well to or tolerate stimulants
not as effective in most people though
Atomoxatine side effect
serious hepatotoxicity in some people
