Exam 10: Marijuana and Stuff

Question 1

Hashish

Answer 1

Marijuana plant resin with super high TCH concentration

Question 2

K-2 and Spice

Answer 2

Synthetic Marijuana

Question 3

Pharmacokinetics of Marijuana

Answer 3

Highly lipid soluble

Accumulates in fat and is slowly released over time

Question 4

High dose effects of marijuana

Answer 4

Paranoia, hallucinations, psychosis

Question 5

Marijuana cardiovascular effects

Answer 5

Tachycardia

Postural hypotension

Question 6

How might marijuana help with glaucoma treatment?

Answer 6

decrease intraocular pressure

Question 7

How might marijuana help cancer patients?

Answer 7

Inhibition of vomiting reflex (antiemetic during chemo)

Question 8

Marijuana toxicities

Answer 8

1. Immunosuppression
2. Lower testosterone
3. Teratogenic
4. Lung damage

Question 9

Medical uses of marijuana (3)

Answer 9

1. Prevention of nausea during chemotherapy
2. Prevention of “wasting” in AIDs
3. Glaucoma/asthma (data shows that it doesnt really work)

Question 10

What is used in native american ceremonies to get high?

Answer 10

Salvia

Question 11

Salvia mechanism

Answer 11

Salvinorin A is an agonist at kappa opioid receptors and D2 dopamine receptors

Question 12

Salvia effects

Answer 12

Hallucinogen (different from other hallucinogens somehow)

Question 13

Krakom

Answer 13

Plant from Thailand that is a stimulant/pain releiver

Question 14

Krakom mechanism

Answer 14

Similar to opioids, but different…

Question 15

Krakom uses

Answer 15

“Legal opioid”
being abused
some use it for pain control or opioid withdrawal

Question 16

What neurotransmitter disturbance is seen in Alzheimer’s?

Answer 16

Decreased ACh in the nucleus basalts of Meynert

Question 17

What drugs can be used to treat Alzheimer’s neurotransmitter disturbance?

Answer 17

Acetylcholinesterase inhibitors
Rivastigmine
Donepezil

Question 18

How effective are acetylcholinesterase inhibitors in treating Alzheimers?

Answer 18

Modest improvement in cognitive function in some, not much in other.
Do not slow the progress of the disease

Question 19

Side effects of donepezil, rivastigmine?

Answer 19

Muscarinic stuff… (leaky)

Question 20

Which acetylcholinesterase inhibitor causes less side effects?

Answer 20

Donepezil

Question 21

Memantine use

Answer 21

Alzheimers

Question 22

Memantine mechanism

Answer 22

NMDA antagonist

also blocks excitatory glutamate at NDMA receptors in the hippocampus and frontal cortex

Question 23

how do vitamin E, seligiline, and deprenyl help with alzheimers

Answer 23

antioxidant properties

controversial aka probably complete bullshit

Question 24

What is the only drug that treats ALS?

Answer 24

Riluzole

Question 25

Riluzole mechanism

Answer 25

inhibits excitatory glutamate

Question 26

Mainstay drug of ADHD therapy

Answer 26

Methylphenidate

Question 27

adderall

Answer 27

d-amphetamine/d,l-amphetamine

reserved for patients who don’t respond to methylphenidate

Question 28

Adderall problem

Answer 28

Schedule II

can complicate prescribing

Question 29

Atomoxatine mechanism

Answer 29

inhibits NE reuptake

Question 30

Atomoxatine use

Answer 30

benefits ADHD patients who don’t respond well to or tolerate stimulants
not as effective in most people though

Question 31

Atomoxatine side effect

Answer 31

serious hepatotoxicity in some people