Estrogens Flashcards
1
Q
Estrogens & Progestins
A
- promotes female maturation
- help regulate ongoing activity of female reproductive organs
- estrogens affect bone mineralization and lipid metabolism
2
Q
Principal Endogenous Estrogen
A
estradiol
3
Q
Therapeutic Uses for Estrogen
A
- hormone therapy after menopause
- female hypogonadism
- acne
4
Q
Routes of administration for Estrogen
A
- oral
- transdermal
- intravaginal
- parenteral
5
Q
Metabolic Actions of Estrogen
A
- positive effect on bone mass
- favorable effects on cholesterol levels
- blood coagulation
6
Q
Adverse Effects of Estrogen
A
- endometrial hyperplasia and carcinoma
- promotes growth of existing breast cancer
- ovarian cancer
- cardiovascular events
- Nausea
- adverse effects from use during pregnancy
7
Q
Selective Estrogen Receptor Modulators (SERMs)
A
- activate in some tissues and block estrogen receptors selectively in others
- developed to provide benefits of estrogen while avoiding the drawbacks
- includes tamoxifen and raloxifene
