Erectile Dysfunction

Question 1

Viagra

Answer 1

• phosphodiesterase type 5 (PDE5) inhibtor 1
• generally well tolerated
• only enhances normal erectile response in the presence of stimuli (no significant impact on men who do not have ED)

Question 2

Adverse effects of Viagra

Answer 2

• hypotension
• priapism
• headache, dyspepsia, flushing, nasal congestion, diarrhea, rash, dizziness, mild transient visual disturbances, intesificaiton of sleep apnea
• rare side effects include nonatreritic ischemic optic neuropathy and sudden hearing loss

Question 3

Viagra Interactions

Answer 3

• absorption slowed by high fat meals

- interacts with nitrates, alpha blockers, and P450 inhibitors negatively

Question 4

Do not take Viagra if

Answer 4

• have had MI, stroke, or life threatening dysrhythmia within last 6 months
• have resting hypotension
• have resting hypertension
• have heart failure
• have unstable angina
• are taking a nitrate

Question 5

Levitra

Answer 5

• PDE5 Inhibitor II

- relaxes arterial and trabecular smooth muscle in the penis

Question 6

Adverse Effects and Drug Interactions of Levitra

Answer 6

• headache and flushinf
• rhinitis and dyspepsia
• can prolong QT interval
• Can lower blood pressure
• can be associated with sudden hearing loss and vision loss
• interacts negatively with nitrates, alpha blockers, and P450 inhibitors

Question 7

Cialis

Answer 7

• PDE5 Inhibitor II
• relaxes penile and arterial trabecular smooth muscle
• lasts up to 36 hours

Question 8

Adverse Effects and Drug Interactions of Cialis

Answer 8

• headaches, dyspepsia, back pain, myalgia, limb pain, flushing, and nasal congestion
• can also be associated with sudden hearing loss and vision loss
• interacts negatively with nitrates and alpha blockers (except tamsulosin)