Esophageal Neoplasms Flashcards
1
Q
What type are most esophageal cancers?
A
Squamous cell carcinoma
2
Q
Etiologic factors contributing to esophageal cancer?
A
- Smoking
- Excessive alcohol consumption
- HPV
- Nitrosamines
- Plummer-Vinson Syndrome
- Chronic Esophagitis
- Chemical Injury
- Webs, rings, diverticula
3
Q
What accounts for the common metastasis of esophageal cancers?
A
The rich lymphatic drainage of the esophagus
4
Q
What is the most common presenting Syx of esophageal cancer?
A
Dysphagia
5
Q
What is the typical issue with progression once a patient presents with dysphagia?
A
The tumor is unresectable
6
Q
From what does adenocarcinoma of the esophagus arise?
A
Barrett Esophagus
7
Q
What is the most common molecular change that occurs in the conversion of Barrett epithelium to adenocarcinoma?
A
Inactivation of the tumor suppressor gene p16
