Equine Pathology Flashcards

1
Q

Adv of open castration

A
  • Simple
  • Quick
  • Excellent drainage
  • Can be done standing
  • Best when incomplete sterility
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2
Q

Disadv of open castration

A
  • Higher risk of complications
  • H+ - testicular a. most sig source
  • Infection
  • Eventration (hernia) - rare but serious
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3
Q

Adv of closed castration

A
  • Reduced incidence of H+ + infection, eventration of intestine
  • More suitable for older horses (large vessels - ligature provides extra haemostasis
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4
Q

Disadv of closed castration

A
  • Inc expense of sterile environment + GA
  • Implant (ligature) can act as focus for infection
  • No drainage
  • No visual check for what’s inside parietal tunic
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5
Q

Adv of semi-closed castration

A
  • Reduced incidence of H+ + infection, eventration of intestine
  • More suitable for older horses (large vessels - ligature provides extra hemostasis
  • Allows inspection inside parietal tunic
  • Better ligament placement = reduced risk of H+
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6
Q

Disadv of closed castration

A
  • Inc expense of sterile environment + GA
  • Implant (ligature) can act as focus for infection
  • No drainage
  • Inc surgical complexity
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7
Q

Indications of GA

A
  • Horse not well handled
  • Pony too small
  • Testes too small or difficult to palpate
  • Closed/semi-closed castration - theatre
  • Older/large horses + donkeys/mules
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8
Q

Local anaesthesia

A
  • Recommended for GA castration
  • Crucial for standing castration
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9
Q

Castration patient selection

A
  • Age - spring of yearling year, can be done before weaned, considerations if older, 1 - 2 y/o
  • Handleable/temperament - on CE + palp
  • Palpation - two testis, scrotal/inguinal hernia?
  • Tetanus vacc (first two)
  • Donkeys, mules; draft breeds (inc risk of eventration - consider closed/semi-closed)
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10
Q

Cryptorchids

A
  • = Rigs
  • Complete abdo
  • Partial abdo (testis in abdomen, epididymis in inguinal region)
  • Inguinal (‘high-flanker’)
  • Not present (congenital monorchid) = rare
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11
Q

Cryptorchid Dx

A
  • Palpation
  • Sedation + deep palpation, feeling right up into inguinal ring
  • US - inguinal -> transabdominal / transrectal - between inguinal ring + kidney
  • Static tests - serum Anti-Mullerian Hormone (AMH) - inc
    (Serum oestrone sulfate + testosterone (not recommended) static test)
  • Dynamic testing - if inconclusive AMH results = hCG stimulation test (pre + post testosterone) - testosterone levels inc
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12
Q

H+ - CS

A
  • Acute blood loss - assess subject (horse blood vol should be 9% BW) - demeanour, HR/pulse, MM/CRT
  • Haematology - PCV, transfusion if PCV < 20%
  • Steady drop/stream = less than a drop per second for excessive period of time, > 15 min = make active intervention for H+
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13
Q

Swelling + oedema

A
  • Common post-op (castration)
  • +/- Seroma infection
  • Exercise crucial
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14
Q

Seroma

A
  • Common w/ open castration
  • Pocket of serum (tinged w/ blood) fills scrotum after Sx
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15
Q

Scrotal infection

A
  • Common in open castration - determine temp, demeanour, dull/inappetant
  • Closed castration - less common - more concerning due to lack of physical drainage, pos presence of implant (ligature)
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16
Q

Iatrogenic penile trauma (castration)

A
  • Root of penis mistaken for testis -> emasculation of root of penis (usually closed castration, cannot see)
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17
Q

Incomplete castration

A
  • Cannot see what you’re emasculating in closed castration
  • Young foal colts have relatively large gubernaculum - mistaken for testes
  • Partial abdo cryptorchids
  • Inexperienced surgeons
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18
Q

Septic funiculitis (‘Scirrhous Cord’) (castration complication)

A
  • Chronic non-healing inflam that keeps recurring + forms discharging sinus tract
  • Palpable thickening
  • Uncommon
  • Not pyrexic when chronic
  • Failure of appropriate antimicrobials = Dx, AB don’t work as well)
  • Absorbable suture can be focus of infection - avoid ligatures in non-sterile Sx
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19
Q

Peritonitis (castration)

A
  • Rare
  • Abdo pain/colic signs
  • Pyrexia
  • V dull
  • Weight loss
  • Dx = abdominocentesis (high cell count + turbid appearance)
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20
Q

Evisceration of omentum (castration)

A
  • Through inguinal hernia
  • Open castration
  • Rare
  • Not Sx emergency
  • Dx = appearance
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21
Q

Evisceration of SI (castration)

A
  • Through inguinal hernia
  • Open castration
  • Rare but serious
  • Fatal w/o Sx Tx (36 - 87% success)
  • Draft breeds + standardbreds
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22
Q

Standing Sx indications

A
  • Castration
  • Laparoscopy - ovariectomy; cryptorchidectomy
  • URT - ventriculotomy; vocal fold resection, tieback (laryngoplasty)
  • Sinus Sx
  • Dental Sx
  • Orthopaedic Sx - non-displaced Fx, DSP (dorsal spinous process) resection), arthroscopy
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23
Q

Laparoscopic Sx indications (standing)

A
  • Cryptorchidectomy
  • Ovariectomy
  • Granulosa cell tumour removal
  • Abdominal exploration
  • Nephrosplenic space closure
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24
Q

Indications for ovariectomy

A
  • Behavioural
  • Colic/abdo pain
  • GCT
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25
Granulosa cell tumour (GCT)
- Often secretory -> inc testosterone, inc inhibin - Stallion-like behaviour, anoestrus or continuous oestrus, normal cycling = rare - Enlarged ovary per rectum - Dx - US - accum large pockets of fluid, biochemically same as CSF; inhibin hormone test
26
Difficulties w/ non-laparoscopic ovaraiectomy
- Haemostasis - Post-operative pain - Prolonged wound healing - Evisceration
27
Abdominal exploration indications
- Recurrent colic - Palpable abdo mass - US findings
28
Contra-indications of abdo exploration
- Acute colic - Intestinal distension - may need to resect intestines, difficult to do laparscopically
29
URT laser Sx
- Vocal cordectomy/ventriculectomy - due to laryngeal hemiplegia - +/- Laryngoplasty - Incisional benefits
30
Colic post-op complications
- Discomfort - Prolonged hospitalisation - Expense
31
Post-op colic complications
- Intestinal obstruction - like kink in water pipe hose - Blockage at anastomosis - Ileus (gut stasis) - Adhesions - Displacement - Failure of adaptation - Inc risk following large colon volvulus > 360 degrees - 50% times more likely to develop after Sx = most common post-op complication
32
Surgical site wound infection
- Painful - Inc risk of hernia formation - Prolonged hospitalisation
33
Post-op incisional herniation
- Wound suppuration - HR = inc, endotoxaemia - ischaemic bowel in abdo, leaking endotoxins, absorbed by circulation, going into bloodstream, effect of endotoxin = systemic -> inflam, affects healing of abdo wall - Median time to appear = 57 d
34
Predispositions of colic
- Horses that have had an episode of colic - Crib-biting/windsucking behaviour
35
Post-op ileus
- 10 - 20% - 80% cases survive - Onset post-op = 24 h - Intestines fills up w/ fluid from upper GIT - no motility - becomes life threatening when SI fluid backs up in stomach, cannot be sick, pressure built up in stomach -> rupture -> release of fluid into peritoneal cavity = death, pass stomach tube to decompress stomach - CS - dull + depressed, inc HR, inc PCV, inc TP, gastric reflux - Inc PCV - endotoxaemia (inhibits GI motility), fluid into SI -> distension - Dx - US - distended gut, swirling food in lumen, normal intestines would not be as empty - Pedunculated lipoma strangulation - 3 x more likely
36
Arthroscopy
- Dx - visualisation of joint - ST structures, cartilage lesions - Therapeutic - OCD/chip Fx; synovial sepsis - Remove bone fragments - Debridement of intra-articular ST injuries - Assist in repair of articular Fx with internal fixation - Debride or inject subchondral bone cysts (Tenoscopy = within tendon sheath; bursoscopy within a bursa)
37
Orthopaedic arthroscopy intra-operative general anaesthesia risks
- Haemarthrosis - articular bleeding into joint cavity - Obstruction of view by synovial villi - Extrasynovial extravasion (leakage) of fluid - Iatrogenic damage to articular cartilage - Intrasynovial instrument breakage - Intrasynovial foreign material - intrument broken off
38
Orthopaedic arthroscopy post-operative general anaesthesia risks
- Infection - Post-op synovitis/distension - Synovial hernia - Failure to remove fragments - Post-op capsulitis, enthesis (sites where tendons + ligaments attach to bones), new bone + ST mineralisation - Pain
39
Fx that involve conservative Tx
- Pedal bone, non-articular - Ileal wing - uncommon, box rest/keep stable for time, detect on US - Incomplete long bone e.g. tibia - Accessory carpal bone
40
Fx that involve Sx removal of bony fragments
- Splint bone (distal) - Carpal chips - P1 extensor process
41
Fx that involve Sx repair
- Mc/Mt condyle - P1 sagittal - Carpal/tarsal slab - Olecranon - Common in racehorses
42
Fx that involve euth
- Comminuted - Open/contaminated - Transverse long bone/large horse
43
Intra-operative GA complications Fx repair
- Myositis - ST damage - Fx extension - Joint penetration - Implant (screw) breakage - Contamination
44
Post-operative GA complications Fx repair
- Fx on recovery - Neuropathy/myopathy on recovery - becomes non-weight bearing on one of limbs e.g. contralateral limb to Fx, pressure from Sx - Infection - Cast sores - Implant failure - Contra-lateral laminitis - Colic - Arthritis (poor joint alignment)
45
Tarsal arthrodesis
- Fusion of bone to joint - Osteoarthritis of TMT + DIT, not responding to medical therapy
46
Impingement/overriding of dorsal spinous processes
- Kissing spines - processes/ligament formation between spinal processes
47
Desmotomy
- Surgical section of ligament - Annular ligament (ligament all around fetlock) constriction - DIP flexural deformity of forelimb - check ligament, seen in young foals
48
Periosteal transection
- Angular limb deformity non-responsive to conservative Tx (hoof trimming, corrective shoes) - Early in life during active growth phase - before 2 m/o
49
Tendon repair
- Partial or complete severance of flexor tendon (extensor tendons managed conservatively) - Repair only attempted if severance cleaned
50
Laser Sx (Standing)
- Ventriculectomy only - Ventriculectomy + cordectomy - Ventriculectomy prior to Tieback - Aryepiglottic fold resection
51
Contraindications of standing Sx for castration
- Behavioural - Size - big horse = big testes, big bloods vv, require emasculators rather than ligatures, H+ risk - Cryptorchid - Older horse
52
Adv standing Sx Fx
- Minimal displacement - Recovery - Dental - mandibular Fx - remove bits of Fx bone/fixation - Applying splints/casts - GA induction/recovery may destroy - If weight-bearing - Skull Fx
53
Dehydration
- SI problem/obstruction - unable to get fluid through to LI
54
4 stages of wound healing
- Inflam (6 - 48 h, swelling, oedema, erythema, most sore) - Haemostasis - reflex vasoconstriction (first 5 - 10 min) -> vasodilation -> haemostatic plug, prevents further fluid loss, dies to form scab -> sloughs off eventually - 1). Inflam phase - migration of leucocytes into wound - neutrophils + monocytes + production of pro-inflam mediators - 2). Debridement phase (7 - 10 d) macrophages remove clot + debride necrotic tissue, pus produced - 3). Proliferative/fibroblastic phase (repair) - pink tissue = new granulation tissue, edges forming - Growth factors stimulate fibroplasia (to contract wound), angiogenesis, epithelialisation -> modify ECM -> granulation tissue (combo of new capillaries, fibroblasts + connective tissue) -> 2 - 3 w - 4). Maturation phase (v v long time, regain full strength + elasticity) - hair follicles - Restoration of skin integrity - wound w/ new tissue
55
Mechanisms of wound healing/closure
- Wound contraction (of myofibroblasts) - reduction in wound size - Granulation - new capillaries, fibroblasts + connective tissue, surface for epithelialisation - Epithelialisation - side-to-side healing of epithelium - on top of fibroblasts, at margin of granulation - First intention - suture - bring edges together, soon after problem, clean wounds/clean-contaminated, no tension or dead space, before granulation, minimal scaring - Second intention - granulation healing, wound contraction + re-epithelialisation, unsuitable for closure, severe contamination + devitalisation + tissue loss, AB needed, allow gap to fill up w/ granulation tissue, slower, more tissue scarring
56
Wound healing problems
- Synovial sepsis - Proud flesh formation - No wound contraction below carpus/tarsus - Sequestrum formation = avascular bone that can harbour infection - Movement
57
Synovial sepsis
- Synovial cavities w/ thin soft tissue coverage of joints/tendon sheaths/bursae - Dx - sudden, onset severe lameness, v painful, synovial fluid sample, turbid synovial fluid (high protein content, inc WBC), synovial WBC > 20 x 10^9/L; protein > 20 g/L, egress of injected sterile fluid (communication of synovial cavity/joint capsule + wound) - If untreated -> sepsis -> severe pain -> articular cartilage destruction - non-treatable, infective, OA
58
Proud flesh formation
- Exuberant granulation tissue - continued proliferating - Deforms wound - Grows beyond wound edges - Looks like sarcoid - Slice/debride off
59
No wound contraction below carpus/tarsus
- Skin cells below do not contain myofibroblasts, cells developed differently on lower limb - Slow to heal - Expensive - If don't do anything, granulation tissue keeps growing - Epithelial tissue - keeps granulation tissue in check - use skin graft - provides myofibroblasts + capillaries - Pinch grafting - tiny piece of skin
60
Sequestrum formation
- = Piece of dead bone - necrosis of outer bone cortex - Wound appears to heal then w - m later, pus, like sinus in skin, pus bursts out - Involucrum = hole in parent bone - Periosteal damage often results in sequestrum formation - Acts as nidus for infection - no blood supply, bacteria won't be killed by host defence mechanisms - Wound can heal over top of sequestrum - Leads to recurrent wound breakdown + discharge - Dx - radio - Particularly on distal limb
61
Equine wound management - movement
- Impedes wound healing - facilitates spread of infection - Prevents wound edges from remaining apposed - Encourages spread of infection
62
Criteria of wound dressings
- Protect wound - Haemostasis - Remove extruded or necrotic tissue - Encourage granulation tissue - Encourage epithelialisation
63
Colic - intestinal obstruction, simple (non-strangulating/ischaemic)
- Fluid + gas won't pass through, will build up in front -> distension, pain, discomfort - Eventually become dehydrated, not secreting fluid secreting higher up in intestines- Pelvic flexure impaction - Faecolith/enterolith - Caecal impaction - Ileal impaction - Ascarids/jejunal impaction
64
Colic - sand impactions
- Inc prevalance - Peri-urban horses/ponies - Large impaction of RDC
65
Intestinal displacements
- Obstruction outside gut, LI in tight space + compressed from outside + can undergo torsion + volvulus, twist around axis -> inflated + distended intestines - Right dorsal displacement - Nephrosplenic entrapment? LDD - Pelvic flexure retroflexion - Partial colon torsion
66
Nephrosplenic entrapment
- Lower grade colic (pain) compared to strangulation (ischaemic) - Colon trapped dorsal to spleen - Gas distension + impaction of trapped colon - Leads to impaction in ventral colon
67
Large colon torsion
- RDD - right dorsal colon - twists/rotates clockwise - Can cause mucosal oedema following ischaemia - esp at pelvic flexure - Once blood supply obstructed - get ischaemic necrosis - Colon = massive SA -> leakage of bacteria from colon into peritoneal cavity -> become sick v quickly - V painful colic - Signs of endotoxaemia - changes in mm colour, inc heart rate - know horse requires Sx
68
Intestinal strangulation - ischaemic + stop blood flow
- Pedunculated lipoma, most common - Epiploic foramen entrapment - anatomical hole bordered by ligaments, intestines may slip through, tight hole, venous supply blocked, so arterial supply occluded -> ischaemic -> endotoxaemia - Mesenteric tears - Gastro-splenic ligament - Volvulus nodosus - Intussusceptions
69
Problems of intestinal strangulation
- Ischaemic gut - Endotoxaemia - Distension proximally
70
Intestinal biopsy
At laparotomy - associated colic Sx Acute colic - Equine grass sickness - evidence of degeneration of enteric nerve undergone necrosis - Eosinophilic enteritis/colitis - Neoplasia - Assessment of gut viability Chronic disease - Infiltrative diseases - Malabsorption
71
Eosinophilic enteritis
72
Limitations of colic Sx
- Adhesions + abscesses - Inaccessible regions - stomach, duodenum, caecal base - incision through abdo, down dorsal wall; (Intestine not mobile at these points; mesentery holds intestines tightly to abdo wall, cannot hold up to wall/exteriorise) - Stomach held so tightly by ligaments in abdomen - hard to evacuate ingesta w/o contaminating peritoneal cavity impossible - Motility disorders - Recurrent displacements - Advanced endotoxaemia - e.g. dorsal colon rupture - Rectal exam - if food material then no other option but to euth as endotoxaemic - Unable to treat as issues w/ managing expectations, communication, at the hospital, time-line, post-op care, convalescence, cost
73
Colic Sx recovery
- 90% resumed athletic activity resumed - 70% back to full activity - 79% O recommend Sx
74
Acute onset lameness top DDx
- Sub-solar abscess - Fracture - Sepsis
75
Anaesthesia risks + complications
- Mortality = 2.1%, 'healthy patients' (not colic/c-section) = 0.9% - due to cardiac arrest (33%) or Fx in recovery and/or myopathy (32.6%) - Cardiac arrest - Cardiac arrhythmia - Neuropathy - Nasal oedema, laryngeal paralysis, pulmonary oedema, resp tract obstruction - Hypoxaemia - Hypotension - Fx - Ileus - Post-op colic - Contributing factors - patient positioning, anaesthetic drugs, pre-exisiting disease, human error
76
Factors that inc risk of anaesthetic death
- Total inhalant anaesthesia - never done for adults, only foals, always have IV induction/total IV - Duration > 2 h - Inc adult age - Out of hours anaesthesia, esp midnight to 6 am
77
Factors that decc risk of anaesthetic death
- Total IV anaesthesia (TIVA) - less than < 90 min; ketamine dec CVS depression compared to effects from inhalants - Duration < 2 h - ACP pre-med - peripheral vasodilation, improving muscle perfusion, preventing myopathy + antiarrhythmic properties
78
Anaesthesia - cardiac arrest
- Most common cause of peri-anaesthetic death - Hoisting the horse (unavoidable) - support head - Respiratory tract obstruction - obligate nasal breathers, use ET tube - Pre-existing disease - Drugs - CVS effects
79
Anaesthesia - nasal oedema
- Can happen with dorsal recumbency - hydrostatic pressure of head below heart - Can lead to obstruction
80
Anaesthesia - hypoxaemia
- PaO2 < 60 mmHg Causes - Low FiO2 (fraction of inspired O2) - Hypoventilation - dorsal recum - Diffusion impairment e.g. pneumonia - V/Q mismatch - areas of lungs perfused but not ventilated + vice versa - all recum horses - Shunt
81
Anaesthesia - hypotension
- MAP < 60 mmHg - Inhalational aneasthesia > TIVA (ketamine) - Peripheral vasodilation: dec peripheral resistance; dec MAP; dec tissue perfusion -> myopathy/neuropathy - Contributing factor for myopathy/neuropathy
82
Other considerations of field anaesthesia
- Location - clean field, indoor or outdoor school, not in stable - Tetanus prophylaxis - Anti-toxin plus vaccine booster if unvaccinated, reschedule elective procedures - Contingency planning - emergency drugs - crash, ET tube- resp tract obstruction, O2 therapy
83
Adverse effects of sedation - alpha-2 agonists
- Sweating - Ataxia - Sinus bradycardia, 1st & 2nd degree AVB, respiratory depression - Increased Urination - Ileus (Starve for a couple of hours after sedation) - Gas distension, colic (repeated administration) - Tachypnoea in febrile horses + also antipyretic - Localised inflammatory response if drug accidentally injected s/c or peri-vascular - Horses can appear profoundly sedated but still startle and react with well-directed kicks - Individual/breed differences in susceptibility – e.g. draft breeds very sensitive to sedation
84
Adverse effects of sedation - opioids
- Reduced GIT motility - but more negative impacts from pain - Ileus - Impaction colic (repeated administration) - Horse can startle
85
Reasons for hospitalisation
- Dx, suspicious of condition, could require emergency Tx/Sx - Don't have facilities/equipment on field/yard - Not comfortable performing procedure - Inexperience - Client request
86
Conditions + presentation that require referral/hospitalisation
- Colic - Sx, recurrent, not responding to medical Tx - Wounds - Sx suturing, risk of synovial sepsis, large/awkward laceration - Synovial sepsis - investigation, joint lavage - Acute lameness - Fx, synovial sepsis, severe tendonitis - Ocular emergencies - globe penetration, melting ulcer, uveitis - can deteriorate rapidly - Severe dehydration/hypovolaemia - investigation, IVFT, constant monitoring - Infectious disease - investigation, Tx, isolation - Myopathies - investigation, supportive care - Lameness - investigation - work-up, advanced imaging, difficult/fractious horse - Medical investigations - weight loss, hepatic disease, poor performance, ataxia
87
Procedures undertaken in hospital
- IV - catheterisation, IVFT, plasma + blood transfusion - Sx - GI - rectal exam, imaging US abdo, biopsy - liver, rectal mucosa, nasogastric tube, oral glucose absorption test, abdominocentesis - CVS - electrocardiogram + echocardiogram - Resp - endoscopy, tracheal aspirate, bronchoalveolar lavage, pleurocentesis, thoracic US, emergency tracheostomy, intranasal O2 admin - MSK - advanced imaging, Dx analgesia, bandaging, splinting, IV regional antibiosis, muscle biopsy, BM biopsy - Neuro - lumbosacral spinal fluid collection, alanto occipital cerebrospinal fluid collection, epidural - Repro - endometrial biopsy - Ocular - regional anaesthesia eye, placement sub palpebral lavage system - Urinary catheterisation, bladder endoscopy - Integument - suture
88
Compare + contrast jugular vein catheters - teflon vs polyurethane
- Teflon = simple, over need, cheap, common, easy to use, but inc irritation, prone to kinking, inc risk of thrombophlebitis - Polyurethane = less rigid, longer placement time, less irritation, reduces risk of thrombus, but inc contamination risk, difficult to place, more expensive
89
D+ - hopsitalised
- Close monitoring for early recognition - temp, CVS, Faecal consistency; abnormal clinical parameters precede the diarrhoea - Nosocomial infection -hospital acquired infection, but may have been incubating infection prior to admission - Infectious - salmonella, clostridial enterocolitis - Warning signs = loose faces +/- pyrexia +/- leucopaenia = ISOLATE - Non-infectious – AB associated, NSAID associated, feed related (dietary change) - commensal bacteria overgrowth e.g. clostridium -> opportunistic infections
90
Thombophlebitis - hospitalised horse
- Indwelling catheters or venepuncture sites - Risk factor: Endotoxaemia, septic or non-septic - CS - heat, pain, swelling, no drainage at the affected site, pyrexia, peripheral venous distension - Monitor daily - remove catheter if signs of thrombophlebitis - Investigation - US for thrombus, C&S of catheter tip - Complications - vegetatie endocarditis
91
Unwillingness to drink + inappetence - hospitalised horse
- Unfamiliar environment and feed - Pain - Systemic effects: Infection, fever, depressed mentation - Investigate inappetence - hyperlipaemia + hyperlipidaemia (blood test), ensure adequate pain control, anorexia part of acute phase response to infection, associated w/ pyrexia
92
Hyperlipaemia
- Cause: inadequate food intake (negative energy balance) exacerbated by underlying disease + obesity - Donkeys and ponies worse affected than horses - Occurs when the rate of lipolysis from adipose stores exceeds the rate of removal of triglyceride from the plasma - Excessive fat deposition causes organ dysfunction - CS - non-specific - depression, anorexia, weakness, ataxia, seizures, signs of liver or other organ failure - Dx - Blood sample - opaque discolouration of plasma; elevated triglycerides but < 5.65 mmol/L = hyperlipidaemia; elevated triglycerides > 5.65 mmol/L = hyperlipaemia
93
Unexplained fever
- Adult > 38.5 C; foal > 38.9 C - Post-op infection - Sx site, catheter, resp tract - Peritonitis - after abdo Sx - Monitor temp - q 2/d
94
Critical care scenarios
CVS system - Colic - endotoxaemia/endotoxic shock - Sepsis/septic shock - Acute Haemorrhage - Seizures/encephalopathies - Atypical myopathy - Sick foals (sepsis, NMS = neonatal maladjustment syndrome)