Energy and Metabolism 2 Flashcards
How to enzymes lower the activation energy?
- Orient substrates correctly- linkages needed to be made are brought closer
- Facilitates bond breaking to reach transition state
- Provides favorable microenvironment
- Changes bond arrangements to make easier attachment
Enzyme functions are affected by the environmental factors such as
pH and temperature
no homeostasis= no functioning enzymes= no _____
metabolism
competitive inhibitors
inhibitor binds to the active site of enzyme, no allowing the lock and key fit to occur
noncompetitive inhibitors
binds to another part of the enzyme to change the overall shape. Enzyme no longer fits into the substrate
Give examples of enzyme inhibitors
poison, toxins, antibiotics
If metabolic pathways are not controlled..
chaos occurs
The main way how cells regulate metabolic pathways are
regulation of genes
regulation of genes-
express more or less of a certain (protein) for example to increase or decrease the presence
allosteric regulation
inhibits or stimulates enzyme’s activity
allosteric regulators are made up of
polypeptide subunits
Name the two types of allosteric regulators
- Allosteric Activator
2. Allosteric Inhibitor
Allosteric Activator
presence of activator exposes the different active sites in a STABLE form
Allosteric inhibitors
presence of inhibitor causes all active sites to be covered in a STABLE form
Allosteric Cooperativity
substrate addition activates other three active sites