Endometriosis Flashcards

1
Q

What is endometriosis

A

Ectopic endometrial tissue outside the uterus

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2
Q

What is a lump of endometrial tissue outside the uterus

A

endometrioma

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3
Q

What are choclate cysts

A

Endometriomas in ovaries

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4
Q

What is adenomyosis

A

endometrial tissue within myometrium of uterus (muscle)

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5
Q

Theories for what causes endometriosis

A

There is a genetic component but none found to directly cause
Retrograde menstruation through fallopian tubes
Embryonic cells -> endometrial tissue outside uterus
Endometrial cells through lymphatic system
Cells outside uterus metaplasia -> endometrial tissue

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6
Q

Why is pelvic pain the main symptoms of endometriosis?

A

Cells of endometrial tissue respond to hormones the same way as in uterus - sheds lining and bleeds -> irritation and inflammation of tissues around endometriosis

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7
Q

Type of pain in menstruation with endometriosis

A

Cyclical, dull, heavy or burining pain

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8
Q

Can blood in the urine or stools be caused by endometriosis

A

In bladder or bowel

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9
Q

What causes chronic cyclical pain in endometriosis

A

Local bleeding and inflammation -> adhesions, scar tissue
Pain ass with sharp, stabbing or pulling + nausea

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10
Q

Why might endometriosis cause infertility

A

Sometimes unclear
Adhesions blocking tubes or ovaries - release of eggs
Damage eggs if adhesions in ovaries

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11
Q

Endometriosis presentation

A

Asymptomatic
Cyclical abdominal or pelvic pain
Deep dyspareunia - pain on deep sexual intercourse
Dysmenorrhoea
Infertility
Cyclical bleeding from other sites eg haematuria

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12
Q

What other systems can have symptoms from endometriosis

A

Urinary, bowel

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13
Q

What is seen on sepculum exam in endometriosis

A

Endometrial tissue visible, particuarly in posterior fornix, tenderness vagina, cervix and adnexa

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14
Q

What see on bimanual exam in endometriosis

A

Fixed cervix on bimanual examination

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15
Q

What can see on pelvic US endometriossi

A

Often unremarkable
Large endometriomas and chcolate cysts

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16
Q

What is gold standard to diagnose abdominal and pelvic endometriosis

A

Laprascopic surgery
Biopsy of lesions during laproscopy
Can also remove depositis if there

17
Q

What is a staging systen to be aware of

A

American society of reproducitve medicine
* Stage 1: Small superficial lesions
* Stage 2: Mild, but deeper lesions than stage 1
* Stage 3: Deeper lesions, with lesions on the ovaries and mild adhesions
* Stage 4: Deep and large lesions affecting the ovaries with extensive adhesions

18
Q

Guidleines for the management of endometriosis

A

RCOG - green top guideline 41 on chronic pelivc pain 2012
ESHRE guidelines on endometriosis
NICE

19
Q

Initial management of endometriosis

A

Establish diagnsois
Clear explanantion
Listening to patient, ICE
analgesia - NSAIDs and paracetemol

20
Q

Hormonal management of endometriosis

A

COCP - can be used back to back without pill free period if needed
Progesterone only pill
Medroxyprogesterone acetate injection - depo-provera
Nexplanon implant
Mirena coil
GnRH agonsits

21
Q

Surgical management for endometriosis

A

Laprascopic surgery to excise or ablate endometrial tissue and remove adhesions (adhesiolysis)
Hysterectomy

22
Q

What is the problem with hormonal treatments for endometriosis

A

Dont improve fertility

23
Q

What is the purpose of hormonal treatment for endometrisosi

A

Stop ovulation
Reduce endometrial thickening

24
Q

What do GnRH agonsits do

A

Induce menopause like state to reduce cyclical pain - shut down ovaries

25
Q

Examples of GnRH agonists

A

Goserelin - zoladex
Leuprorelin - prostap

26
Q

Side effects of GnRH agonists

A

Hot flushes, night sweats, risk of osteoporosis