endocrine system Flashcards
gap junctions
interactions of cells
neurotransmitters
communications for nerves
hormones
chemical messengers that travel through the blood stream
Both nervous and endocrine system communicate through chemical messengers to
bind ti target cells to produce a response
can a hormone and neurotransmitter produce the same response
yes
whats the differences between nervous and endocrine system
nervous is faster, stops as soon as stimuli stops , not redundant, very specific target
endocrine is not as fast, will keeps going if stimuli stops, wide range target.
exocrine glands
secret products through ducts to body surfaces (skin)
examples of exocrine glands
mucous, sweat oil, saliva, bile, and pancreatic enzymes
2 types of chemical messengers
autocrines paracrines
autocrines
exert their effects in the same cell that secretes them
paracrines
( same tissue) but different types of cells than the releasing the signal
three types of hormones
peptide, steroid, eicosonoids
what type of hormone is water soluble
peptide
what type of hormone is fat soluble
steroid
how do peptide hormone get into the cell
by a second messenger, bind to g protein
what is the steriod hormone synthesized from and where
from cholesterol in gonads from adrenal glands
are eicosonoids autocrines or paracrine
both
why are eicosoniods released by many cells
in response inflammation and immunity
most common types of eicosoniods
leukotrienes, prostaglandins
three types of hormone release
humoral, neutral stimuli, hormonal stimuli
where is the pituitary gland located
sella turcica in sphenoid bone
two parts of pituitary gland
anterior pituitary, posterior pituitary
hormones secreted by posterior pituitary
oxytocin, antidiuretic hormone
abrev for antidiuretic hormone
ADH
oxytocin is secreted by
paraventricular nucleus of hypothalamus
what stimulates oxytocin
cervical/ uterine stretching and suckling on infant at breasts
what inhibits oxytocin
lack of appropriate neural stimuli
what is the target organ on oxytocin
uterus breast
what is not a true gland
posterior pituitary
what hormone stimulates uterine contractions, initiates labor initiates milk injection
oxytocin
antidiuretic hormone ADH is secreted by
neurons of supraoptic nucleus of hypothalamus
what stimulates ADH
if an increase of blood solute concentration or decrease of blood volume is needed. pain, some drugs, low blood pressure
what inhibits ADH
adequate hydration of the body, alcohol
what is the target organ of ADH
kidneys
what hormone stimulates kidney tubule cells to reabsorb water
ADH
hypo secretions of ADH
diabetes insipidus
hyper secretions of ADH
syndrome of inappropriate ADH secretion (SIADH)
what hormones are secreted by anterior pituitary
growth hormone thyroid-stimulating hormone adrenocorticotropic hormone follicle-stimulating hormone luteinizing hormone, prolactin
what stimulates GH
release of growth hormone releasing hormone, low blood levels of GH
what inhibits GH
feedback inhibition exerted by GH AND IGF, hyperglycemia
IGF
insulin like growth factor
what is the target of GH
liver, muscle, bone, cartilage and other tissues
what hormone stimulates somatic growth, mobilizes fats, spares glucose
GH
hypo secretion of GH
Pituitary dwarfism children
hyper secretion of GH
gigantism in children and acromegaly in adults
what stimulates Thyroid-Stimulatting hormone (TSH)
thyroid releasing hormone, in infants-cold temperature
what inhibits TSH
by feedback inhibition exerted by thyroid hormones
what is the target of TSH
thyroid gland
what hormone stimulates thyroid gland to release thyroid hormones
TSH
what stimulates Adrenocorticotropic hormone (ACTH)
by CRH, stimuli that releases CRH is stressors
what inhibits ACTH
by feedback inhibition exerted by glucocorticoids
what is the target organ of ACTH
adrenal cortex
what hormone promotes release of glucocorticoids and androgens (mineralocorticoids)
ACTH
hypo secretion of ACTH
rare
hyper secretions
cushings disease
what stimulates Follicle stimulating hormone (FSH)
GnRH
what inhibits FSH
feedback inhibition exerted by inhibin, estrogens-f testosterone-m
what are the target organs of FSH
ovaries and testes
what hormone stimulates ovarian follicle maturation and production of estrogens and stimulates sperm production
FSH
hypo secretion of FSH
failure of sexual maturation
hyper secretion of FSH
no important effects
what stimulates Luteinizing hormone (LH)
by GnRH
what inhibits LH
by inhibition exerted by estrogens and progesterone in women and testosterone in males
what are the target organs of LH
ovaries and testes
what hormone triggers ovulation and stimulates ovarian production of estrogens and progesterone and promotes testosterone production
LH
hyposecretion of LH
failure of sexual maturation
hyper secretion of LH
no important effects
what stimulates prolactin (PRL)
decrease of Prolactin inhibiting hormone, release of enhanced by estrogen, birth control pills, breast feeding, dopamine-blocking drugs
what inhibits PRL
prolactin inhibiting hormone
what is the target organ of PRL
breast secretory tissue
what hormone promotes location
PRL
hypo secretion of PRL
poor milk production in nursing women
hypersecretion of PRL
galactorrhea, cessation of menses in females , impotence in males
galactorrhea
inappropriate milk production
what stimulates Mineralocorticoids (Aldosterone)
reninangiotensinaldosterone mechanism
what activates reninangiotensinaldosterone mechanism
decreasing blood volumes blood pressure elevates mood K+ level and ACTH
what inhibits Mineralocorticoids
increased blood volume and pressure and decreased blood K+ levels
What is the target organ of Mineralocorticoids
kidneys
what hormone increases blood levels of na and decrease blood levels of k and blood volume and blood volume rises
mineralocorticoids
hypo secretion mineralocorticoids
aldosteronism
hyper secretion
Addison’s disease
what stimulates glucocorticoids (cortisol)
ACTH
what inhibits cortisol
feedback inhibition exerted by cortisol
hypo secretion of cortisol
cushings syndrome
hyper secretion of cortisol
Addisons disease
what stimulates gonadocorticoids (androgens)
ACTH
what is converted to testosterone or estrogen after release
androgens
what hormone contributes to female libido development of pubic and axillary hair in females and source of estrogens after menopause
gonadocorticoids
hypo secretion of gonadocorticoids
adrenogenital syndrome
adrenogenital syndrome
masculinization of females
what hormones are secreted in adrenal cortex
mineralocorticoids glucocorticoids gonadocorticoids
what hormones are secreted in the adrenal medulla
catecholamines
what are examples of catecholamines
epinephrine and norepinephrine
what stimulates catecholamines
preganglionic fibers of the sympathetic nervous system
what hormone increases heart rate and metabolic rate and increase blood pressure
catecholamines
what are the target organs of catecholamines
sympathetic nervous system target organs
hyper secretions of catecholamines
prolonged fight tor flight responses or hypertension
what horses does the thyroid hormone
thyroxine, triiodothyronine, calcitonin
thyroxine T4
follicle cells of thyroid
triiodothyronine T3
follicle cells
calcitonin
parafollicular cells
what stimulates thyroxine
TSH TRH
what inhibits thyroxine
negative feedback to pituitary and hypothalamus
what hormone promotes oxygen utilization and increases the metabolic rate
thyroxine
hypo secretion of thyroxine
hypothyroidism Hashimoto’s and cretinism in children
hyper secretion of thyroxine
hyperthyroidism graves disease
what stimulates calcitonin
increased calcitonin levels in blood
where is calcitonin target
bone
what hormone decreases calcium levels by promoting calcium deposition kidneys and promotes calcium exception
calcitonin
what stimulates parathyroid hormone PTH
a decrease calcium levels in blood
where is PTH target
bone; kidney
what hormone increases osteoclast activity and increases calcium reabsorption into blood
PTH
hypo secretion of PTH
hypoparathyroidism
hyper secretion PTH
hyperparathyroidism
PTH does what
maintains the body calcium and phosphate
goiter
enlargement of the thyroid gland
what causes goiters
iodine defiency
what synthesize and release PTH
parathyroid cells or chief cells
PTH activates
osteoclasts
too much PTH causes
osteitis fibrosa cáustica
pineal gland composed of
pineocytes
pineal gland function
produce melatonin
what affects circadian rhythm
melatonin
what surpasses melatonin secretion
exposure to bright light
where is the location of the T cells of T lymphocytes
thymus gland
superior portion of adrenal
adrenal cortex
what is the name given to all adrenal hormones
corticosteroids
what are the layers of the adrenal cortex
glumerulosa, fascisulata, reticularis
glumerulosa/mineralcorticoids
na, k and water balance
fascisulata/ glucocorticoids
cortisol glucose metabolism
reticularis /gonadocortticoids
sex hormones
what is a hyper secretion of cortisol
cushings syndrome
adrenal medulla
postganglionic sympathetic neurons
what is the major function of postganglionic sympathetic neurons
produce catecholamines
catecholamines in children
neuroblasma
catecholamines in adults
pheochromocytoma
symptoms of pheochromocytoma
increased blood pressure and palpitations
where is the pancreas
elongated gland below and behind stomach
pancreas is divided into four parts
head neck body and tall
what is the pancreas responsible for
to regulate glycemic (blood sugar)
does pancreas have endocrine or exocrine functions
both
acinar cells
produce digestive enzymes (exocrine )
types of islets of langerhans cells
Alpha, bets, dela cells
alpha cells secrets
glucagon
beta cells secrete
insulin
delta cells secrete
somatostatin
when is glucagon released
between meals when blood glucose concentration is falling
what does glucagon do in the liver
stimulates gluconeogensis glucogenolysis and release of glucose in circulation raising blood glucose level
what does glucagon do in adipose tissue
stimulates fat catabolism and release of free fatty acids
when is insulin secreted
during and after meal when glucose and amino acid blood levels are rising
what three things does insulin do
lowering blood glucose levels, promotes synthesis glycogen, fat, protein and suppresses use of already stored fuels
what three things can absorb glucose without insulin
brain liver and kidneys
type 1
insulin dependent
type 2
non insulin dependent
what type of cells do type 1 destroy
beta cells
before what age do you get type 1
30
is type 1 obesity related
no
is type 1 ketoacidosis
yes
what are symptoms of type 1 and 2
polyuria, polydipsia, thirst, weight loss
what is important about type 2
resistance to insulin
does type 2 require insulin
maybe
is diabetic ketoacidosis dangerous
yes a medical emergency
what is diabetic ketoacidosis due to
elevated insulin requirements from physical or mental stress
somatostatin suppressers
secretion of glucagon and insulin
somatostatin inhibits
nutrient digestion and absorption which prolongs absorption of nutrients
liver converts
cholecalciferol into calcidiol
liver secrets
angiotensingen (a pro-hormone)
hepcidin
promotes intestinal absorption of iron
kidneys
convert calcidiol to calcitroil, active form of vitamin D
kidneys secrets
renin
kidneys produces
erythropoietin
heart
atrial muscle secrets two natriuretic peptides in response to an increase in blood pressure
stomach and small intestine
secrete enteric hormones to coordinate digestive motility and glandular secretion
example of enteric hormones
cholecystokinin and gastrin
adipose tissure secrets
leptin
what is secreted by osteoblast
osteocalcin
placenta increases
estrogen, progesterone
in female ovary, granulosa
cell produce most of estradiol during reproductive years
what is converted from cholesterol precursor molecules under the direction of FSH LH
estradiol
what are the gonads
ovaries and testes
testes produce
testosterone and small amount of estrogen
what is testes function
to develop male characteristics in uterus and secondary sex characteristics in puberty
tests maintains
good sperm production
what controls the testes
FSH LH