Endocrine Mechanisms Flashcards
Main functional difference between endocrine and exocrine glands?
Exocrine glands only work locally and cannot affect organs in a distance
Releases a product via exocytosis
Merocrine (Eccrine)
Ex. Sweat glands
Releases products by membrane budding
Apocrine
Ex. Mammary glands
Releases products via membrane rupture and cell lysis
Holocrine glands
Ex. Sebaceous glands
T or F. Pancreas gland is both an exocrine and endocrine gland.
True. It releases digestive enzymes to GI tract through pancreatic duct and releases key hormones (insulin and glucagon)
T or F. Some molecules can act as both neurotransmitters and hormones
True. Ex. Norepinephrine, oxytocin, and antidiuretic hormone (ADH)
These hormones are one or multiple chains of amino acids (can be few amino acids to a lot)
Peptide hormones
These hormones are derived from the lipid cholesterol
Steroid hormones
T or F. The steroid hormones like lipid cholesterol contain its characteristic 5 ring structure
False. 4 ring structure!
Steroid hormones are (hydrophobic/ hydrophilic) vs peptide hormone are (hydrophobic/ hydrophilic)
Steroid: hydrophobic
Peptide: Hydrophilic
T or F. Peptide hormones can travel around the polar aqueous bloodstream without the need for blood transport proteins. However they cannot diffuses through cell membrane and therefore, binds to cell membrane receptors causing a cascade inside the cell through second messengers.
True
Common secondary messengers
cAMP, IP3, and Ca2+
T or F. Peptide hormones are associated with slow and long term changes
False. Rapid and short-term changes because they are hydrophilic
T or F. Because of steroid hormone’s hydrophobicity, it requires a carrier protein to travel along the bloodstream
True
Example of carrier proteins that shield steroid hormones to the environment
Sex hormone binding globulin and Albumin (binds a variety of nonpolar compounds)
Steroid hormones influences the transcription which makes its effect (faster/ slower) and has (shorter/ longer) effects
Slower ; longer
Steroid hormones production
The molecules are synthesized from cholesterol in the smooth ER and diffuse directly through the cell membrane into the vascular system
Peptide hormones production
- Transcription of relevant mRNA from associated DNA
- Translation of mRNA into a polypeptide in ribosome
- This polypeptide is called preprohormone-early precursor to mature peptide hormone
- Preprohormone enter a secretory pathway for secretion from its cell of origin
- during translation, the preprohormone is threaded into the rough ER where it become prohormone- immediate precursors of active peptide hormones
- Travel to Golgi apparatus where they are cleaved by peptidases and sometimes modified by glycoslyation
- Then they become fully functional peptide hormones
- Leave golgi in vesicles and leave to circulation through exocytosis
Hormones that are small molecules that are derived from a single amino acid
Amino acid derivatives
T3 and T4 are derived from tyrosine and acts more like (peptide/ steroid) hormone
Steroid
Epinephrine and norepinephrine acts more like (peptide/ steroid) hormone
Peptide (water-soluble)
Epinephrine and norepinephrine are?
Catecholamines
Melatonin is a derivative of which amino acid solubility property
Tryptophan ; amphipathic