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Pharmacology > Endocrine Drugs > Flashcards

Endocrine Drugs Flashcards

1
Q

Leupropride

A

Long acting GnRH agonist

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2
Q

Tamoxifen

A

SERM

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3
Q

Endometriosis DOC

A

Long acting GnRH agonists

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4
Q

Mifepristone (RU 486)

A

Anti-progestin and anti-glucocorticoid

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5
Q

Toremifene

A

SERM

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6
Q

Fulvestrant

A

Full estrogen receptor antagonist

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7
Q

Spironolactone

A

Androgen receptor antagonist and aldosterone antagonist

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8
Q

Dutasteride

A

5 alpha reductase inhibitor

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9
Q

Urofollitropin

A

FSH gonadotropin

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10
Q

Clomiphene

A

SERM

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11
Q

Letrozole

A

Aromatase inhibitor

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12
Q

Flutamide

A

Androgen receptor antagonist

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13
Q

Gosereline

A

Long acting GnRH agonist

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14
Q

Cetroelix

A

GnRH antagonist

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15
Q

Finasteride

A

5 alpha reductase inhibitors

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16
Q

Tolbutamide

A

Sulfonylurea

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17
Q

Metformin

A

DOC for DMII

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18
Q

Miglitol

A

alpha-glucosidase inhibitor

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19
Q

Bromocriptine

A

Dopamine agonist

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20
Q

Ganirelix

A

GnRH antagonist

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21
Q

hMG

A

FSH gonadotropin

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22
Q

Reloxifene

A

SERM

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23
Q

Canagliflozin

A

SGLT2 inhibitor

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24
Q

Glipizide

A

Sulfonylurea

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25
Q

Rosiglitazone

A

Thiasolidinediones

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26
Q

Exenatride

A

incretin mimetic

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27
Q

Stiagliptin

A

DDP IV inhibitors

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28
Q

hCG

A

LH gonadotropin

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29
Q

Pre-menopausal breast cancer DOC

A

Tamoxifen

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30
Q

Anastrole

A

Aromatase inhibitors

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31
Q

Danazol

A

Anti-progestin (week progestin and androgen)

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32
Q

Acarbose

A

alpha- glucosidase inhibitor

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33
Q

Lispro (humalog)

A

Rapid acting insulin

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34
Q

Degludec

A

Long acting insulin

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35
Q

Exemastane

A

Aromatase inhibitor

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36
Q

Tolazadmide

A

Sulfonylurea

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37
Q

Pioglitazone

A

TZD

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38
Q

Diazoxide

A

Non-diuretic thiazide (used in insulinomas). Decreases insulin secretion.

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39
Q

Glargine

A

Long acting insulin

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40
Q

Glipizide

A

Sulfonylurea

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41
Q

Nateglinide

A

Meglitinides

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42
Q

Linagliptin

A

DDP IV inhibitors

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43
Q

Ergonovbine maleate

A

Ergot alkaloids

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44
Q

DOC for inducing labor

A

oxytocin

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45
Q

Dinoprostone

A

Prostaglandin

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46
Q

Nifedipine

A

CCB

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47
Q

Indomethacin

A

NSAID to reduce prostaglandin synthesis

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48
Q

NPH

A

Intermediate acting insulin

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49
Q

Regular insulin

A

short acting

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50
Q

Isophane insulin

A

intermediate acting

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51
Q

Chlorpropamide

A

sulfonylurea

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52
Q

Liraglutide

A

incretin mimetic

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53
Q

Pramlintide

A

amylin analog

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54
Q

Empagliflozin

A

SGLT2 inhibitor

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55
Q

Detemir

A

Long acting insulin

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56
Q

Methylergonovine

A

ergot alkaloid

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57
Q

glimiperide

A

sulfonylurea

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58
Q

Repaglinide

A

Meglitinides

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59
Q

Dulaglutide

A

Incretin mimetic

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60
Q

Alogliptin

A

DDP IV inhibitor

61
Q

Dapagliflozin

A

SGLT2 inhibitor

62
Q

Colesevelam

A

bile acid binding resin

63
Q

Glargine

A

Long acting insulin

64
Q

Magnesium sulfate

A

uterine relaxant

65
Q

Nitroglycerin

A

uterine relaxant

66
Q

Levothyroxine

A

T4

67
Q

Propranolol

A

beta blocker that blocks peripheral conversion of t4 to t3

68
Q

Denosumab

A

Antibody against RANKL

69
Q

Aledronate

A

Bisphosphonate

70
Q

Pamidronate

A

Bisphosphonate

71
Q

Methimazole

A

Thioamides

72
Q

Liothyronine

A

T3

73
Q

Teriparatide

A

Recombinant PTH

74
Q

Zoledronic acid

A

Bisphosphonate

75
Q

Hydrocortisone/cortisone

A

Glucocorticoids with mineral corticoid activity. Replacment therapy.

76
Q

Flucticasone

A

Anti-inflammator glucocorticoid

77
Q

Ketoconazole

A

Corticosteroid inhibitor

78
Q

Ibandronate

A

bisphosphonate

79
Q

Etidronate

A

bisphosphonate

80
Q

Propylthiouracil (PTU)

A

Thioamide

81
Q

Risedronate

A

bisphosphonate

82
Q

Prednisone/prednisolone

A

Glucocorticoid

83
Q

Triamcinolone

A

Anti-inflammatory glucocorticoid

84
Q

Dexamethasone

A

Anti-inflammatory glucocorticoid

85
Q

Fludrocortisone

A

Aldosterone glucocorticoid

86
Q

Aminoglutethimide

A

corticosteroid inhibitor

87
Q

DOC for infertility

A

Clomiphene (clomid) SERM

88
Q

DOC for post menopausal Breast CA

A

Aromatase inhibitors

89
Q

Prophylaxis of DM

A

TZDs (Pioglitazine)

90
Q

Insulins Used IV

A

Rapid (lispro, aspart, glulisine) and short (regular) acting

91
Q

Type II DM drugs that cause weight loss

A

Incretin mimetics and pramlintide

92
Q

Type II DM drugs that are injected

A

Incretin Mimetics and pramlintide

93
Q

Type II DM drugs that can cause hypoglycemia

A

Sulfonylureas and Meglitinides

94
Q

Post partum hemorrhage choices

A

Massage, Oxytocin, Ergot Alkaloids, Corboprost Tromethamine.

95
Q

DOC for cervical ripening

A

Dinoprostone

96
Q

Corboprost Tromethamine

A

Prostaglandin

97
Q

DOC for hypothyroid

A

Levothyroxine

98
Q

DOC for Graves

A

Thioamides (methimazole)

99
Q

DOC for post- menopausal osteoporosis

A

Bisphosphonates

100
Q

Oral Bisphosphonates

A

Aledronate, Risedronate, Ibandronate, Etidronate

101
Q

IV Bisphosphonates

A

Ibandronate, Etidronate, Zoledronic Acid, Pamidronate

102
Q

DOC hyproparathyroidism

A

Teriparatide

103
Q

DOC hypoaldersteronism

A

Fludrocortisone

104
Q

DOC for Adrenal insufficiency

A

Hydrocortisone/Cortisone

105
Q

SERM MOA

A

Antagonist in the breast, agonist in the bone and uterus (except reloxifene)

106
Q

Aromatase Inhibitor MOA

A

Blocks sythesis of estrogens

107
Q

Mifepristone MOA

A

Progesterone and glucocorticoid receptor antagonist

108
Q

5 alpha reductase MOA

A

Inhibits the synthesis of DHT

109
Q

Sulfonylureas MOA

A

Block K channels to stimulate insulin release

110
Q

Meglitinide MOA

A

Similar to sulfonylureas (but not sulfa drugs)

111
Q

Thiazolidinediones MOA

A

Ligand for PPAR-gamma receptor to increase insulin sensitivity

112
Q

Alpha-glucosidease inhibitor

A

Reduces carbohydrate digestion and absorption

113
Q

Incretin Mimetic MOA

A

Increase insulin release and slows gastric emptying

114
Q

Pramlintide MOA

A

Analog of amylin. Supresses post prandial glucagon release. Used as an adjunct to insulin therapy.

115
Q

SGLT2 inhibitors MOA

A

Glucose is peed out

116
Q

Ergot Alkaloid MOA

A

Strong contraction of uterine muscle via serotonin and alpha-adrenergic receptors

117
Q

Thioamides MOA

A

Decreases synthesis and release of T4. Blocks peripheral conversion.

118
Q

Propranolol MOA

A

Beta blocker that also blocks peripheral conversion of T4 to T3

119
Q

Teriparatide MOA

A

Recombinant PTH. Produces bone growth.

120
Q

Calcitonin MOA

A

Antagonizes PTH

121
Q

Denosumab MOA

A

antibody to the RANKL inhibits osteoclast activity.

122
Q

Bisphosphonate MOA

A

PCP analog that is incorporated into the bone

123
Q

Diarrhea Drugs

A

Metformin, quinidine, dinoprostone, erythromycin, colchicine

124
Q

Gonadotropin side effects

A

Ovarian hyperstimulation

125
Q

SERM used for osteoporosis

A

Reloxifene

126
Q

Androgen uses

A

Testicular deficiency, hypopituitarism (Women), Nephrosis and Negative N balance.

127
Q

Flutamid Uses

A

Prostate cancer along with a long-acting GnRH agonist

128
Q

5 alpha reductase uses

A

BPH and baldness

129
Q

Type II DM drugs that can cause hypoglycemia

A

sulfonylureas, meglitinides, insulin

130
Q

Prophylactic DM II drugs

A

TZDs (pioglitazone)

131
Q

Metformin side effects

A

Lactic Acidosis and Diarrhea

132
Q

Metformin Contraindications

A

Lactic acid conditions: renal/hepatic disease, hypoxia (CHF, COPD)

133
Q

TZD side effects

A

Weight gain, edema

134
Q

TZD contraindications

A

hepatic disease and CHF. Rosiglitazone has black box warning for increased risk of MI/stroke

135
Q

Incretin mimetic side effects

A

Pancreatitis

136
Q

DDP IV inhibitor side effects

A

Pancreatitis

137
Q

alpha glucosidase inhibitors

A

Flatulence

138
Q

The Sulfonylureas

A

tolbutamide, chlorpropamide, tolazadmide, glyburide, glipezide, glimiperide

139
Q

The meglitinides

A

Repaglinide, nateglinide

140
Q

The alpha glucosidase inhibitors

A

Acarbose, miglitol

141
Q

The incretin mimetics

A

Exenatride, liraglutide, dulaglutide

142
Q

The aromatase inhibitors

A

Anastrol, letrozole, exemastane.

143
Q

Oxytocin side effects

A

Water intoxication, uterine rupture, bradycardia of the fetus

144
Q

Dinoprostone side effects

A

Diarrhea

145
Q

Indomethacin side effects

A

Partial closure of the ductus arteriosus

146
Q

PTU side effects

A

Acute liver failure. Only used if allergic to methimazole or pregnant

147
Q

The Thioamides

A

PTU and methimazole

148
Q

The corticosteroid inhibitors

A

aminoglutethimide and ketoconazole

Pharmacology (24 decks)

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