Endocrine Drugs Flashcards
Leupropride
Long acting GnRH agonist
Tamoxifen
SERM
Endometriosis DOC
Long acting GnRH agonists
Mifepristone (RU 486)
Anti-progestin and anti-glucocorticoid
Toremifene
SERM
Fulvestrant
Full estrogen receptor antagonist
Spironolactone
Androgen receptor antagonist and aldosterone antagonist
Dutasteride
5 alpha reductase inhibitor
Urofollitropin
FSH gonadotropin
Clomiphene
SERM
Letrozole
Aromatase inhibitor
Flutamide
Androgen receptor antagonist
Gosereline
Long acting GnRH agonist
Cetroelix
GnRH antagonist
Finasteride
5 alpha reductase inhibitors
Tolbutamide
Sulfonylurea
Metformin
DOC for DMII
Miglitol
alpha-glucosidase inhibitor
Bromocriptine
Dopamine agonist
Ganirelix
GnRH antagonist
hMG
FSH gonadotropin
Reloxifene
SERM
Canagliflozin
SGLT2 inhibitor
Glipizide
Sulfonylurea
Rosiglitazone
Thiasolidinediones
Exenatride
incretin mimetic
Stiagliptin
DDP IV inhibitors
hCG
LH gonadotropin
Pre-menopausal breast cancer DOC
Tamoxifen
Anastrole
Aromatase inhibitors
Danazol
Anti-progestin (week progestin and androgen)
Acarbose
alpha- glucosidase inhibitor
Lispro (humalog)
Rapid acting insulin
Degludec
Long acting insulin
Exemastane
Aromatase inhibitor
Tolazadmide
Sulfonylurea
Pioglitazone
TZD
Diazoxide
Non-diuretic thiazide (used in insulinomas). Decreases insulin secretion.
Glargine
Long acting insulin
Glipizide
Sulfonylurea
Nateglinide
Meglitinides
Linagliptin
DDP IV inhibitors
Ergonovbine maleate
Ergot alkaloids
DOC for inducing labor
oxytocin
Dinoprostone
Prostaglandin
Nifedipine
CCB
Indomethacin
NSAID to reduce prostaglandin synthesis
NPH
Intermediate acting insulin
Regular insulin
short acting
Isophane insulin
intermediate acting
Chlorpropamide
sulfonylurea
Liraglutide
incretin mimetic
Pramlintide
amylin analog
Empagliflozin
SGLT2 inhibitor
Detemir
Long acting insulin
Methylergonovine
ergot alkaloid
glimiperide
sulfonylurea
Repaglinide
Meglitinides
Dulaglutide
Incretin mimetic
Alogliptin
DDP IV inhibitor
Dapagliflozin
SGLT2 inhibitor
Colesevelam
bile acid binding resin
Glargine
Long acting insulin
Magnesium sulfate
uterine relaxant
Nitroglycerin
uterine relaxant
Levothyroxine
T4
Propranolol
beta blocker that blocks peripheral conversion of t4 to t3
Denosumab
Antibody against RANKL
Aledronate
Bisphosphonate
Pamidronate
Bisphosphonate
Methimazole
Thioamides
Liothyronine
T3
Teriparatide
Recombinant PTH
Zoledronic acid
Bisphosphonate
Hydrocortisone/cortisone
Glucocorticoids with mineral corticoid activity. Replacment therapy.
Flucticasone
Anti-inflammator glucocorticoid
Ketoconazole
Corticosteroid inhibitor
Ibandronate
bisphosphonate
Etidronate
bisphosphonate
Propylthiouracil (PTU)
Thioamide
Risedronate
bisphosphonate
Prednisone/prednisolone
Glucocorticoid
Triamcinolone
Anti-inflammatory glucocorticoid
Dexamethasone
Anti-inflammatory glucocorticoid
Fludrocortisone
Aldosterone glucocorticoid
Aminoglutethimide
corticosteroid inhibitor
DOC for infertility
Clomiphene (clomid) SERM
DOC for post menopausal Breast CA
Aromatase inhibitors
Prophylaxis of DM
TZDs (Pioglitazine)
Insulins Used IV
Rapid (lispro, aspart, glulisine) and short (regular) acting
Type II DM drugs that cause weight loss
Incretin mimetics and pramlintide
Type II DM drugs that are injected
Incretin Mimetics and pramlintide
Type II DM drugs that can cause hypoglycemia
Sulfonylureas and Meglitinides
Post partum hemorrhage choices
Massage, Oxytocin, Ergot Alkaloids, Corboprost Tromethamine.
DOC for cervical ripening
Dinoprostone
Corboprost Tromethamine
Prostaglandin
DOC for hypothyroid
Levothyroxine
DOC for Graves
Thioamides (methimazole)
DOC for post- menopausal osteoporosis
Bisphosphonates
Oral Bisphosphonates
Aledronate, Risedronate, Ibandronate, Etidronate
IV Bisphosphonates
Ibandronate, Etidronate, Zoledronic Acid, Pamidronate
DOC hyproparathyroidism
Teriparatide
DOC hypoaldersteronism
Fludrocortisone
DOC for Adrenal insufficiency
Hydrocortisone/Cortisone
SERM MOA
Antagonist in the breast, agonist in the bone and uterus (except reloxifene)
Aromatase Inhibitor MOA
Blocks sythesis of estrogens
Mifepristone MOA
Progesterone and glucocorticoid receptor antagonist
5 alpha reductase MOA
Inhibits the synthesis of DHT
Sulfonylureas MOA
Block K channels to stimulate insulin release
Meglitinide MOA
Similar to sulfonylureas (but not sulfa drugs)
Thiazolidinediones MOA
Ligand for PPAR-gamma receptor to increase insulin sensitivity
Alpha-glucosidease inhibitor
Reduces carbohydrate digestion and absorption
Incretin Mimetic MOA
Increase insulin release and slows gastric emptying
Pramlintide MOA
Analog of amylin. Supresses post prandial glucagon release. Used as an adjunct to insulin therapy.
SGLT2 inhibitors MOA
Glucose is peed out
Ergot Alkaloid MOA
Strong contraction of uterine muscle via serotonin and alpha-adrenergic receptors
Thioamides MOA
Decreases synthesis and release of T4. Blocks peripheral conversion.
Propranolol MOA
Beta blocker that also blocks peripheral conversion of T4 to T3
Teriparatide MOA
Recombinant PTH. Produces bone growth.
Calcitonin MOA
Antagonizes PTH
Denosumab MOA
antibody to the RANKL inhibits osteoclast activity.
Bisphosphonate MOA
PCP analog that is incorporated into the bone
Diarrhea Drugs
Metformin, quinidine, dinoprostone, erythromycin, colchicine
Gonadotropin side effects
Ovarian hyperstimulation
SERM used for osteoporosis
Reloxifene
Androgen uses
Testicular deficiency, hypopituitarism (Women), Nephrosis and Negative N balance.
Flutamid Uses
Prostate cancer along with a long-acting GnRH agonist
5 alpha reductase uses
BPH and baldness
Type II DM drugs that can cause hypoglycemia
sulfonylureas, meglitinides, insulin
Prophylactic DM II drugs
TZDs (pioglitazone)
Metformin side effects
Lactic Acidosis and Diarrhea
Metformin Contraindications
Lactic acid conditions: renal/hepatic disease, hypoxia (CHF, COPD)
TZD side effects
Weight gain, edema
TZD contraindications
hepatic disease and CHF. Rosiglitazone has black box warning for increased risk of MI/stroke
Incretin mimetic side effects
Pancreatitis
DDP IV inhibitor side effects
Pancreatitis
alpha glucosidase inhibitors
Flatulence
The Sulfonylureas
tolbutamide, chlorpropamide, tolazadmide, glyburide, glipezide, glimiperide
The meglitinides
Repaglinide, nateglinide
The alpha glucosidase inhibitors
Acarbose, miglitol
The incretin mimetics
Exenatride, liraglutide, dulaglutide
The aromatase inhibitors
Anastrol, letrozole, exemastane.
Oxytocin side effects
Water intoxication, uterine rupture, bradycardia of the fetus
Dinoprostone side effects
Diarrhea
Indomethacin side effects
Partial closure of the ductus arteriosus
PTU side effects
Acute liver failure. Only used if allergic to methimazole or pregnant
The Thioamides
PTU and methimazole
The corticosteroid inhibitors
aminoglutethimide and ketoconazole