Endocrine Drugs Flashcards
1
Q
Leupropride
A
Long acting GnRH agonist
2
Q
Tamoxifen
A
SERM
3
Q
Endometriosis DOC
A
Long acting GnRH agonists
4
Q
Mifepristone (RU 486)
A
Anti-progestin and anti-glucocorticoid
5
Q
Toremifene
A
SERM
6
Q
Fulvestrant
A
Full estrogen receptor antagonist
7
Q
Spironolactone
A
Androgen receptor antagonist and aldosterone antagonist
8
Q
Dutasteride
A
5 alpha reductase inhibitor
9
Q
Urofollitropin
A
FSH gonadotropin
10
Q
Clomiphene
A
SERM
11
Q
Letrozole
A
Aromatase inhibitor
12
Q
Flutamide
A
Androgen receptor antagonist
13
Q
Gosereline
A
Long acting GnRH agonist
14
Q
Cetroelix
A
GnRH antagonist
15
Q
Finasteride
A
5 alpha reductase inhibitors
16
Q
Tolbutamide
A
Sulfonylurea
17
Q
Metformin
A
DOC for DMII
18
Q
Miglitol
A
alpha-glucosidase inhibitor
19
Q
Bromocriptine
A
Dopamine agonist
20
Q
Ganirelix
A
GnRH antagonist
21
Q
hMG
A
FSH gonadotropin
22
Q
Reloxifene
A
SERM
23
Q
Canagliflozin
A
SGLT2 inhibitor
24
Q
Glipizide
A
Sulfonylurea
25
Rosiglitazone
Thiasolidinediones
26
Exenatride
incretin mimetic
27
Stiagliptin
DDP IV inhibitors
28
hCG
LH gonadotropin
29
Pre-menopausal breast cancer DOC
Tamoxifen
30
Anastrole
Aromatase inhibitors
31
Danazol
Anti-progestin (week progestin and androgen)
32
Acarbose
alpha- glucosidase inhibitor
33
Lispro (humalog)
Rapid acting insulin
34
Degludec
Long acting insulin
35
Exemastane
Aromatase inhibitor
36
Tolazadmide
Sulfonylurea
37
Pioglitazone
TZD
38
Diazoxide
Non-diuretic thiazide (used in insulinomas). Decreases insulin secretion.
39
Glargine
Long acting insulin
40
Glipizide
Sulfonylurea
41
Nateglinide
Meglitinides
42
Linagliptin
DDP IV inhibitors
43
Ergonovbine maleate
Ergot alkaloids
44
DOC for inducing labor
oxytocin
45
Dinoprostone
Prostaglandin
46
Nifedipine
CCB
47
Indomethacin
NSAID to reduce prostaglandin synthesis
48
NPH
Intermediate acting insulin
49
Regular insulin
short acting
50
Isophane insulin
intermediate acting
51
Chlorpropamide
sulfonylurea
52
Liraglutide
incretin mimetic
53
Pramlintide
amylin analog
54
Empagliflozin
SGLT2 inhibitor
55
Detemir
Long acting insulin
56
Methylergonovine
ergot alkaloid
57
glimiperide
sulfonylurea
58
Repaglinide
Meglitinides
59
Dulaglutide
Incretin mimetic
60
Alogliptin
DDP IV inhibitor
61
Dapagliflozin
SGLT2 inhibitor
62
Colesevelam
bile acid binding resin
63
Glargine
Long acting insulin
64
Magnesium sulfate
uterine relaxant
65
Nitroglycerin
uterine relaxant
66
Levothyroxine
T4
67
Propranolol
beta blocker that blocks peripheral conversion of t4 to t3
68
Denosumab
Antibody against RANKL
69
Aledronate
Bisphosphonate
70
Pamidronate
Bisphosphonate
71
Methimazole
Thioamides
72
Liothyronine
T3
73
Teriparatide
Recombinant PTH
74
Zoledronic acid
Bisphosphonate
75
Hydrocortisone/cortisone
Glucocorticoids with mineral corticoid activity. Replacment therapy.
76
Flucticasone
Anti-inflammator glucocorticoid
77
Ketoconazole
Corticosteroid inhibitor
78
Ibandronate
bisphosphonate
79
Etidronate
bisphosphonate
80
Propylthiouracil (PTU)
Thioamide
81
Risedronate
bisphosphonate
82
Prednisone/prednisolone
Glucocorticoid
83
Triamcinolone
Anti-inflammatory glucocorticoid
84
Dexamethasone
Anti-inflammatory glucocorticoid
85
Fludrocortisone
Aldosterone glucocorticoid
86
Aminoglutethimide
corticosteroid inhibitor
87
DOC for infertility
Clomiphene (clomid) SERM
88
DOC for post menopausal Breast CA
Aromatase inhibitors
89
Prophylaxis of DM
TZDs (Pioglitazine)
90
Insulins Used IV
Rapid (lispro, aspart, glulisine) and short (regular) acting
91
Type II DM drugs that cause weight loss
Incretin mimetics and pramlintide
92
Type II DM drugs that are injected
Incretin Mimetics and pramlintide
93
Type II DM drugs that can cause hypoglycemia
Sulfonylureas and Meglitinides
94
Post partum hemorrhage choices
Massage, Oxytocin, Ergot Alkaloids, Corboprost Tromethamine.
95
DOC for cervical ripening
Dinoprostone
96
Corboprost Tromethamine
Prostaglandin
97
DOC for hypothyroid
Levothyroxine
98
DOC for Graves
Thioamides (methimazole)
99
DOC for post- menopausal osteoporosis
Bisphosphonates
100
Oral Bisphosphonates
Aledronate, Risedronate, Ibandronate, Etidronate
101
IV Bisphosphonates
Ibandronate, Etidronate, Zoledronic Acid, Pamidronate
102
DOC hyproparathyroidism
Teriparatide
103
DOC hypoaldersteronism
Fludrocortisone
104
DOC for Adrenal insufficiency
Hydrocortisone/Cortisone
105
SERM MOA
Antagonist in the breast, agonist in the bone and uterus (except reloxifene)
106
Aromatase Inhibitor MOA
Blocks sythesis of estrogens
107
Mifepristone MOA
Progesterone and glucocorticoid receptor antagonist
108
5 alpha reductase MOA
Inhibits the synthesis of DHT
109
Sulfonylureas MOA
Block K channels to stimulate insulin release
110
Meglitinide MOA
Similar to sulfonylureas (but not sulfa drugs)
111
Thiazolidinediones MOA
Ligand for PPAR-gamma receptor to increase insulin sensitivity
112
Alpha-glucosidease inhibitor
Reduces carbohydrate digestion and absorption
113
Incretin Mimetic MOA
Increase insulin release and slows gastric emptying
114
Pramlintide MOA
Analog of amylin. Supresses post prandial glucagon release. Used as an adjunct to insulin therapy.
115
SGLT2 inhibitors MOA
Glucose is peed out
116
Ergot Alkaloid MOA
Strong contraction of uterine muscle via serotonin and alpha-adrenergic receptors
117
Thioamides MOA
Decreases synthesis and release of T4. Blocks peripheral conversion.
118
Propranolol MOA
Beta blocker that also blocks peripheral conversion of T4 to T3
119
Teriparatide MOA
Recombinant PTH. Produces bone growth.
120
Calcitonin MOA
Antagonizes PTH
121
Denosumab MOA
antibody to the RANKL inhibits osteoclast activity.
122
Bisphosphonate MOA
PCP analog that is incorporated into the bone
123
Diarrhea Drugs
Metformin, quinidine, dinoprostone, erythromycin, colchicine
124
Gonadotropin side effects
Ovarian hyperstimulation
125
SERM used for osteoporosis
Reloxifene
126
Androgen uses
Testicular deficiency, hypopituitarism (Women), Nephrosis and Negative N balance.
127
Flutamid Uses
Prostate cancer along with a long-acting GnRH agonist
128
5 alpha reductase uses
BPH and baldness
129
Type II DM drugs that can cause hypoglycemia
sulfonylureas, meglitinides, insulin
130
Prophylactic DM II drugs
TZDs (pioglitazone)
131
Metformin side effects
Lactic Acidosis and Diarrhea
132
Metformin Contraindications
Lactic acid conditions: renal/hepatic disease, hypoxia (CHF, COPD)
133
TZD side effects
Weight gain, edema
134
TZD contraindications
hepatic disease and CHF. Rosiglitazone has black box warning for increased risk of MI/stroke
135
Incretin mimetic side effects
Pancreatitis
136
DDP IV inhibitor side effects
Pancreatitis
137
alpha glucosidase inhibitors
Flatulence
138
The Sulfonylureas
tolbutamide, chlorpropamide, tolazadmide, glyburide, glipezide, glimiperide
139
The meglitinides
Repaglinide, nateglinide
140
The alpha glucosidase inhibitors
Acarbose, miglitol
141
The incretin mimetics
Exenatride, liraglutide, dulaglutide
142
The aromatase inhibitors
Anastrol, letrozole, exemastane.
143
Oxytocin side effects
Water intoxication, uterine rupture, bradycardia of the fetus
144
Dinoprostone side effects
Diarrhea
145
Indomethacin side effects
Partial closure of the ductus arteriosus
146
PTU side effects
Acute liver failure. Only used if allergic to methimazole or pregnant
147
The Thioamides
PTU and methimazole
148
The corticosteroid inhibitors
aminoglutethimide and ketoconazole
