Autonomic Nervous system

Question 1

M1 receptor location

Answer 1

Sweat glands and the CNS

Question 2

M1 receptor mechanism

Answer 2

Gq

Question 3

Gq effects

Answer 3

activate PLC to produce IP3 and DAG. Increases calcium and activates protein kinases.

Question 4

M2 receptor location

Answer 4

Heart, presynaptically.

Question 5

M2 receptor mechanism

Answer 5

Gi

Question 6

Gi effects

Answer 6

inhibits adenylyl cyclase, opens potassium channels and hyperpolarizes the cell.

Question 7

M3 receptor locations

Answer 7

Ciliary muscle, iris circular muscle, endothelium, bronchioles, bladder, sphincters, GI.

Question 8

M3 receptor mechanism

Answer 8

Gq

Question 9

Nicotinic Nn receptor locations

Answer 9

postganglionic neurons and presynaptic terminals

Question 10

Nicotinic Nm receptor locations

Answer 10

skeletal muscle

Question 11

Nicotinic mechanism

Answer 11

Increases Na influx and depolarizes the cell

Question 12

Alpha 1 receptor locations

Answer 12

Iris radial muscle, skin vessels, penis

Question 13

Alpha 1 receptor mechanism

Answer 13

Gq

Question 14

Alpha 2 receptor locations

Answer 14

GI smooth muslce, presynaptically

Question 15

Beta 1 receptor locations

Answer 15

Heart, kidney.

Question 16

Beta 1 receptor mechanism

Answer 16

Gs

Question 17

Gs effects

Answer 17

Stimulates adenylyl cyclase causing depolarizaiton

Question 18

Beta 2 receptor locations

Answer 18

Skeletal muscle vessels, bronchioles, bladder, liver

Question 19

Beta 2 receptor mechanism

Answer 19

Gs

Question 20

Beta 3 receptor locations

Answer 20

lipocytes

Question 21

Beta 3 receptor mechanism

Answer 21

Gs

Question 22

D1, D5 receptor locations

Answer 22

brain and renal vascular bed

Question 23

D1, D5 receptor mechanism

Answer 23

Gs

Question 24

D2, D3, D4 receptor locations

Answer 24

brain and other tissues

Question 25

D2, D3, D4 receptor mechanism

Answer 25

Gi

Question 26

Alpha 1 on the iris

Answer 26

Contracts the radial muscle. Causes Mydriasis.

Question 27

M3 on the iris

Answer 27

Contracts the circular muscle. Causes Miosis.

Question 28

Beta on the lens

Answer 28

Relaxes ciliary muscle to accommodate far vision.

Question 29

M3 on the lens

Answer 29

Contracts the ciliary muscle to accommodate for near vision.

Question 30

M3 on intraocular pressure

Answer 30

Decreases IO pressure

Question 31

Alpha 1 on intraocular pressure

Answer 31

Decreases IO pressure

Question 32

Beta on intraocular pressure

Answer 32

Increases IO pressure

Question 33

Beta 1 on the heart

Answer 33

Increases HR and contractility

Question 34

M2 on the heart

Answer 34

Decreases HR ad contractility

Question 35

Alpha on blood vessels

Answer 35

vasoconstriction of skin and splanchnic vessels

Question 36

Beta 2 on blood vessels

Answer 36

vasodialtion of skeletal muscle vessels

Question 37

Beta 2 on bronchioles

Answer 37

bronchodilates

Question 38

M3 on bronchioles

Answer 38

bronchoconstricts

Question 39

alpha 2 on GI tract

Answer 39

Relaxes

Question 40

Beta 2 on GI tract

Answer 40

Relaxes

Question 41

M3 on GI tract

Answer 41

contracts

Question 42

alpha 1 on GI sphincters

Answer 42

contracts

Question 43

M3 on GI sphincters

Answer 43

relaxes

Question 44

M3 on gastric secretions

Answer 44

Increases

Question 45

Beta 2 on bladder

Answer 45

relaxes

Question 46

M3 on bladder

Answer 46

contracts

Question 47

Alpha 1 on bladder sphincter

Answer 47

contracts

Question 48

M3 on bladder sphincter

Answer 48

relaxes

Question 49

Beta 2 on uterus

Answer 49

relaxes

Question 50

Alpha on penis

Answer 50

Ejaculations

Question 51

M on penis

Answer 51

Erection

Question 52

M on eccrine glands

Answer 52

increases

Question 53

alpha on apocrine (stress) glands

Answer 53

increases

Question 54

Beta 3 on fat cells

Answer 54

lipolysis

Question 55

Beta 1 on kidneys

Answer 55

increased renin release

Question 56

Beta 2/alpha on liver

Answer 56

gluconeogenesis and glycogenolysis