Anti HIV Flashcards
Nucleoside Reverse Transcriptase Inhibitors (NRTI) MOA
Nucleoside analogues that require phosphorylation (from host cell) and are then incorporated into the DNA to inhibit viral reverse transcriptase.
NRTI common side effects
Hepatotoxicity and Lactic Acidosis
Zidovudine (retrovir) MOA
NRTI. Thymidine analogue
Zidovudine (retrovir) uses
Maintains CD4 counts, slows progression, used prophylactically, safe in pregnancy. Often combined with lamivudine.
Zidovudine (retrovir) toxicity
CNS (HA), myelosuppression (could be treated with epogen or neupogen), when used with acyclovir can cause lethary.
Lamivudine (epivir) MOA
NRTI. Cytosine analogue.
Lamivudine (epivir) uses
Often combined with zidovudine as an alternate to the first choice. Also used to treat HBV.
Lamivudine (epivir) toxicity
well tolerated. HA, fatigue, insomnia, GI.
Tenofovir (viread) + Emtricitabine (emtriva) use
This combination is the DOC for HIV infections.
Tenofovir (viread) MOA
NRTI. Adenosine analogue.
Emtricitabine (emtriva) MOA
NRTI. Cytosine analogue.
Tenofovir (viread) + Emtricitabine (emtriva) toxicity
flatulence
Didanosine (videx) MOA
NRTI. Adenosine analogue
Didanosine (videx) toxicity
Peripheral neuropathy, hyperuricemia, pancreatitis
Stavudine (zerit) MOA
NRTI. Thymidine analogue.
Stavudine (zerit) toxicity
peripheral neuropathy
Zalcitabine (hivid) MOA
NRTI. Cytosine analogue.
Zalcitabine (hivid) toxicity
peripheral neuropathy especially if diabetic, alcoholic or B12 deficient.
Drugs that cause peripheral neuropathy
NRTIs: Didanosine, stavudine, zalcitabine
Abacavir (ziagen) MOA
NRTI. Guanosine analogue.
Abacavir (ziagen) uses
often combined with lamivudine/zidovudine
Abacavir (ziagen) toxicity
hypersensitivity and GI disturbance
Non-nucleotide reverse transcriptase inhibitors (NNRTI) MOA
Bind directly to inhibit viral reverse transcriptase. Doesn’t require any phosphorylation to be activated.
Efavirenz (sustiva) MOA
NNRTI
Efavirenz (sustiva) uses
DOC for initial therapy. Used in combination with NRTIs.