Antimalarials Flashcards
P. Falciparum
Malignant tertian malaria. Most lethal. Fever occurs every third day. No secondary tissue forms. Cerebral malaria. Has many drug resistant forms.
P. Vivax
Benign tertian malaria. Fever occurs every third day. Has dormant forms in the liver (hypnozoites). Relapses for months/years. Duffy antigen was thought to be protective but isn’t.
P. ovale
Rare. Has secondary tissue forms in the liver (hypnozoites). Relapses.
P. Malariae
Quartan malaria. Fever occurs every four days. No tissue forms but can cause chronic infection.
Blood Schizonticides
Act on RBC forms. Provide a clinical cure for vivax and ovale and a radical cure for malariae and faliparum.
Tissue schizonticides
Act on the hepatic stages. Doesn’t effect the symptoms. Kill vivax and ovale to prevent relapse.
Gametocidal agents
Eliminate proliferation. Doesn’t cure the disease just sloes the spread.
Malaria DOC
Chloroquine
Chloroquine (aralen) resistance
especially falciparum due to efflux pumps.
Chloroquine MOA
Actively concentrate in plasmodia food vacule where they interfere with the degradation of hemoglobin producing a toxic by product.
Chloroquine kinetics
Oral. accumulates in melanin-rich tissue. metabolized by CYP3A4.
Cholorquine toxicity
retinal/corneal toxicity, ototoxicity, hemolysis (G6PD deficiency), QT prolongation.
Cholorquine contraindications
psoriasis and porphyria.
Mefloquine (Lariam) uses
Second-line drug for cholorquine-resistant strains.
Mefloquine toxicity
- ) depression of the myocardium, potential cardiac toxicity. (don’t combine with quinine).
- ) seizures and aggravation of latent psychoses.
- ) sleep and behavioral disturbances, vivid dreams
- ) teratogenic