Anti coagulants Flashcards

1
Q

Heparin MOA

A

Acts as catalyst for antithrombin III

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2
Q

Heparin Indications

A

Prophylaxis for DVT and PE. Used in surgery and IV placement.

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3
Q

Heparin Pharmacokinetics

A

IV only with an immediate onset of action

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4
Q

Heparin Adverse effects

A

Hemorrhage (treat with protamine sulfate), Heparin induced thrombocytopenia.

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5
Q

Enoxaparin

A

LMW heparin

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6
Q

Fondaparinux

A

Synthetic pentasaccharide of heparin

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7
Q

LMW heparin pharmacokinetics

A

Injected Subcutaneously.

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8
Q

LMW heparin indications

A

Used in pregnancy. Lower incidence of HIT.

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9
Q

Lepirudin

A

Direct thrombin Inhibitor, IV only.

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10
Q

Lepirudin Indications

A

HIT alternative to heparin with Renal excretion (used in liver failure)

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11
Q

Argatroban

A

Direct thrombin inhibitor, IV only.

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12
Q

Argatroban Indications

A

HIT alternative to heparin with liver metabolism (used for renal failure)

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13
Q

Dabigatran

A

Direct thrombin inhibitor. Oral.

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14
Q

Rivaroxaban

A

Oral inhibitor of factor Xa

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15
Q

Apixaban

A

Oral inhibitor of factor Xa

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16
Q

Edoxaban

A

Oral inhibitor of factor Xa

17
Q

Warfarin MOA

A

Inhibits vitamin K epoxidase to stop the synthesis of coagulation factors II, VII, IX and X.

18
Q

Warfarin Adverse effects

A

Quickly reduces the levels of protein C so thrombosis can occur within the first few days. Co administer with heparin.

19
Q

Warfarin reversal

A

Vitamin K or fresh frozen plasma

20
Q

Warfarin contraindications

A

Pregnancy.

21
Q

Warfarin Drug interactions

A

Antibiotic absorption, estrogen, aspirin.

22
Q

Thrombolytic agents MOA

A

Converts plasminogen to plasmin with lyses thrombus from within.

23
Q

Thrombolytic agents indications

A

MI, PE, DVT

24
Q

Aminocaproic acid

A

Inhibits plasminogen activation. Used in bleeding disorders and reversal of fibrinolytic therapy.

25
Transexamic acid
Inhibits plasminogen activation. Used in bleeding disorders and reversal of fibrinolytic therapy.
26
Alteplase
Clot selective thrombolytic
27
Reteplase
Clot selective thrombolytic
28
Tenecteplase
Clot selective thrombolytic
29
Aspirin MOA
Irreversibly inhibits COX for the lifetime of the platelet
30
Aspirin indications
Secondary prevention of CV evens with established CV disease.
31
Clopidigrel MOA
Irreversibly blocks the ADP receptor to inhibit platelet aggregation.
32
Ticlopidine MOA
Irreversibly blocks the ADP receptor to inhibit platelet aggregation.
33
DOC for thrombosis prevention in stent placement
Clopidigrel
34
Abciximab
Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.
35
Eptifibatide
Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.
36
Tirofiban
Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.