endocrine Flashcards
1
Q
what are the causes of goitres
A
graves multinodular goitre physiological iodine deficiency lithium infective cancer
2
Q
what investigations should you do for goitres
A
thyroid function tests imaging USS, CT needle aspiration biopsy
3
Q
what is cushings disease
A
ACTH producing pituitary tumour
4
Q
what is the most common cause of ectopic ACTH secretion
A
small cell lung cancer
5
Q
what are the most common causes of ACTH independent cushings syndrome
A
iatrogenic
adrenal tumour
adrenal hyperplasia
6
Q
what are the features of cushings syndrome
A
fat redistrubution skin bruising striae mood changes proximal myopathy hypertension impaired glucose tolerance diabetes pigmentation hypokalaemia
7
Q
what investigations can you do for cushings
A
overnight dexamethasone suppression test
24 hour urinary cortisol
midnight cortisol
plasma ACTH
CT adrenals/ thorax
high dose dexamethasone suppression test
MRI pituitary
8
Q
what medications can be used
A
metyrapone
ketoconazole
