Endocrine

Question 1

What basic laboratory tests should be ordered for 46XX DSD?

Answer 1

1. 17-OHP
2. Serum lytes
3. Glucose
4. ACTH
5. Renin
6. Testosterone
7. LH
8. FSH

Question 2

What basic laboratory tests should be ordered for 46XY DSD?

Answer 2

1. Testosterone
2. DHEAS
3. LH
4. FSH
5. Mullerian inhibiting substance
6. Electrolytes
7. Glucose

Question 3

What happens with 21-hydroxylase deficiency?

Answer 3

Elevation of 17-OHP

Most common cause of CAH

Question 4

What is the best laboratory test to diagnose Cushing syndrome?

Answer 4

24h urinary free cortisol

Question 5

What does reduced serum Ca result in?

Answer 5

Stimulation of PTH which:

1. increases bone resorption
2. decreases urinary loss
3. increases 1,25(OH)vit D production

Question 6

What does elevated serum Ca result in?

Answer 6

Suppression of PTH which:

1. decreases bone resorption
2. increases urinary loss
3. decreases 1,25-OH vitamin D production

Question 7

What is the role of PTH?

Answer 7

Increase calcium

Question 8

What is a T score in DEXA scans?

Answer 8

Comparison to adult means

Question 9

What is a Z score in DEXA scans?

Answer 9

Comparison to age and gender matched peers