Endocrine/1

Question 1

six types of oral hypoglys. treat type 2 dm

Answer 1

1. sulfonylureas
2. meglitinides
3. biguanides
4. thiazolidinediones
5. alpha-glycosidase inhibitors
6. gliptins

Question 2

sulfonylureas rx ex

2

Answer 2

1. glipizide

2. tolbutamide

Question 3

sulfonylureas pharm action

Answer 3

stim. release of insulin

Question 4

sulfonylureas (glipizide, toblutamide) s/e

3

Answer 4

1. mild hypogly.
2. N
3. D

Question 5

sx of hypogly.

5

Answer 5

1. diaphoresis
2. tachycardia
3. fatigue
4. excessive hunger
5. tremors

Question 6

sulfonylureas (glipizide, toblutamide) - contraindication

2

Answer 6

1. pregnant

2. DKA

Question 7

sulfonylureas (glipizide, toblutamide) + alcohol

Answer 7

increases hypoglycemic effects

Question 8

sulfonylureas (glipizide, toblutamide) + NSAIDs

Answer 8

increase hypoglycemic effects

Question 9

meglitinides rx ex

2

Answer 9

1. repaglinide

2. nateglinide

Question 10

sulfonylureas (glipizide, toblutamide) - pts who won’t respond to these won’t respond to what other DM2 drug

Answer 10

meglitinides

Question 11

DM2 - usually prescribed for newly dx diabetics

Answer 11

biguanides - metformin

Question 12

biguanide rx

1

Answer 12

metformin

Question 13

metformin s/e

4

Answer 13

1. ND
2. anorexia
3. vit. def - b12, folic acid
4. lactic acidosis

Question 14

when do you give metformin

2

Answer 14

1. orally with morning and evening meals
   OR
2. once a day with evening meals

Question 15

metformin can cause lactic acidosis - avoid what

Answer 15

alcohol

Question 16

thiazolidinedione rx

1

Answer 16

pioglitazone

Question 17

thiazolidinedione (pioglitazone) s/e

3

Answer 17

1. fluid retention
2. hepatotoxicity
3. increase serum lipid levels

Question 18

s/e include fluid retention, hepatotoxicity, increase serum lipid levels

Answer 18

thiazolidinedione (pioglitazone)

Question 19

gliptins s/e

4

Answer 19

1. upper respiratory tract infection
2. inflamed nasal passages
3. headache
4. pancreatitis

Question 20

gliptins - interventions

3

Answer 20

1. monitor for resp. tract infection and inflamed nasal passages
2. monitor for headache
3. monitor for GI effects that could be signs of pancreatitis

Question 21

3 types of injectable hypoglycemics

3

Answer 21

1. insulin
2. amylin mimetics
3. incretin mimetics

Question 22

insulin therap uses

3

Answer 22

1. DM1
2. DM2
3. gestational DM

Question 23

insulin s/e

3

Answer 23

1. hypogly
2. hypokalemia
3. lipohypertrophy

Question 24

mix insulin glargine or detemir

Answer 24

do not mix with others

Question 25

amylin mimetics therap uses

2

Answer 25

DM1

DM2

Question 26

amylin mimetic rx

1

Answer 26

pramlintide

Question 27

pramlintide is to

Answer 27

amylin mimetic

Question 28

amylin mimetic (pramlintide) s/e
3

Answer 28

1. hypogly.
2. nausea
3. injection site reaction

Question 29

incretin mimetics therap uses

1

Answer 29

1. DM2

Question 30

incretin mimetic rx

1

Answer 30

exenatide

Question 31

exenatide is to

Answer 31

incretin mimetics

Question 32

incretin mimetic (exenatide) s/e
3

Answer 32

1. gi upset
2. hypogly.
3. pancreatitis