Endo 1 Flashcards
What is Diabetes Insipidus?
Inadequate secretion or insensitivity to ADH, leading to ‘Hypotonic Polyuria’
What are the two types of Diabetes Insipidus?
Cranial/Central: Failure of the posterior pituitary to secrete ADH
Nephrogenic: Collecting ducts become insensitive to ADH
What causes Cranial/Central Diabetes Insipidus?
Pituitary Tumour
Infection (Meningitis)
Sarcoidosis
What can cause Nephrogenic DIabetes Insipidus
Hypercalcaemia
Hypokalaemia
Lithium
Inherited Genes (AVPV2)
Idiopathic
How would a patient with Diabetes Insipidus typicall present?
Polyuria (incl. nocturia)
Polydipsia
Symptoms of Hypernatraemia (Lethargy, Irritability, Confusion)
How would you investigate a potential case of Diabetes Insipidus?
U&Es, Glucose
Water Deprivation Test
How is a water deprivation test used to diagnose Diabetes Insipidus?
Water restricted for 8 hours, with plasma and urine osmolality measured every hour.
Give Desmopressin after 8 hours and measure urine osmolality.
In cranial DI - Increase of >50% post-desmopressin
In nephrogenic DI - Increase of <45% post-desmopressin
How do you manage a patient with Diabetes Insipidus?
Treat the underlying cause
Intranasal Desmopressin (Cranial)
Thiazide Diuretics/NSAIDS (Nephrogenic)
How do T1DM and T2DM differ in terms of presentations?
Both present with Polyuria + Polydipsia
T1 presents with Tiredness, weight loss, DKA,
How does a patient experiencing a DKA present?
Nausea and Vomiting
Abdominal Pain
Kussmaul Breathing
Sweet Breath
What are the risk factors for T1 and T2 DM?
T1 - HLA DR3/4, Other autoimmune conditions
T2 - Obesity, FHx, ethnicity, endocrine disease, drug use.
How is Diabetes Mellitus diagnosed?
Fasting Glucose >7 mmol/L
Random Glucose >11.1 mmol/L
How is T1DM managed?
Insulin
Education
Fluids for DKA
How is T2DM managed?
Diet and Lifestyle advice
Metformin +/- sulphonylurea +/- Insulin
What are the main causes of Hyponatraemia?
Hypovolaemic - Diarrhea, Vomiting, Diuretics
Euvolaemic - Hypothyroidism, Hypoadrenalism, SIADH
Hypervolaemia - HF, Cirrhosis, Nephrotic Syndrome
How would you investigate a euvolaemic patient with Hyponatraemia?
TFTs
Short synACTHen test
Drug Review
Breast Exam
CXR/Brain MRI (For tumour - SIADH)
How would you determine the volaemic status of a patient with hyponatraemia?
Hypo - Reduced turgor, postural hypotension, dry mucous membranes
Hyper - Oedematous, High JVP
How does Hypernatraemia present?
Lethargy, irritability, thirst, dehydration, confusion, coma, fits.
What may cause Hypernatraemia?
Rare
Vomiting
Diarrhoea
DI
Primary Aldosteronism
What is SIADH?
Syndrome of Innappropriate ADH secretion.
Not a diagnosis
Need to find an underlying cause.
What can cause SIADH?
CNS Pathology
Lung Pathology
Drugs: SSRI, TCA, Opiates, PPIs, Carbamazepine
Tumours (don’t forget breast)