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Bch 204 > Eicosanoids > Flashcards

Eicosanoids Flashcards

1
Q

PROSTAGLANDINS

-C____ fatty acids are the precursors for prostaglandins

A

20

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2
Q

prostaglandins were thought to originate in the ____

A

prostate

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3
Q

in mid 50s it was isolated from body fluids In ether extract (PGE)

T/F

A

T

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4
Q

Eicosanoids are Made by all cells except _____

A

RBC

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5
Q

EICOSANOIDS

-are ___ hormones , ___ated from _____ acid

A

local

oxygen

arachidonic

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6
Q

Arachidonic acid is a 20C with ______ bonds

A

4 double

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7
Q

prostaglandin ___ is the most potent ___genous ______ substance (sleep wake cycle)

A

D2

Endo

sleep-promoting

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8
Q

Eicosanoids have profound physiological effects at very ____ concentration

A

low

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9
Q

Eicosanoids are hormone-like

T/F

A

T

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10
Q

Eicosanoids are paracrine

T/F

A

T

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11
Q

Eicosanoids bind to ______ receptors and affect _____

A

G-coupled

cAMP

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12
Q

ASPIRIN

  • aspirin inhibits ____
  • ___mg% of aspirin daily is usually prescribed for hypertensive patient
A

Eicosanoids

75

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13
Q 
FUNCTIONS 
Eicosanoids mediate:
-\_\_\_\_\_\_\_\_
-production of \_\_\_ and \_\_\_\_
-regulate blood \_\_\_\_ 
-induction of blood \_\_\_ 
-\_\_\_\_\_ functions 
-\_\_\_\_\_\_ cycle 
-egress of \_\_\_\_\_\_\_
A

inflammation

pain and fever

pressure

clotting

reproductive

sleep/wake

T lymphocytes

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14
Q

arachidonic acid is synthesized from the essential ____ acid (C__:—), 692, by _____ and _____

A

linoleic

18:2

elongation and desaturation

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15
Q

arachidonic acid is phospholipid bound(___,__)

A

Sn2,PI

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16
Q

Arachidonic acid is released upon stimuli by :

1) phospholipase ___
2) phospholipase ___
3) ______ by DAG ____

A

A2

C

DAG hydrolysis

lipase

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17
Q

phospholipase C breaks down phosphatidylinositol into ______ and ____ leaves as a by product

A

DAG

Phosphoinositol

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18
Q

corticosteroids (directly or indirectly?) inhibit PH signaling

A

Indirectly

19
Q

DAG is converted to ____ acid by ______

A

Phosphatidic

P+ins -> PA(DAG kinase ) -> AA(PLA2)

20
Q

Phosphatidic acid is converted to _____ acid and _____ acid by _____

A

lysophosphatidic

arachidonic

phospholipase A2

21
Q

THE REACTIONS CATALYZED BY PGH SYNTHASE

  • PGHS catalyzes ___ step in __ pathway
  • ________+________ activity
  • heme activates _____
  • target of ____
  • _____ membrane protein
A

first; cyclic

cyclooxygenase (COX) + peroxidase

tyr radical

aspirin

monotopic

22
Q

ASPIRIN

  • aka _____ acid
  • (inhibits or aids ?) cyclooxygenase activity of PGHS
  • acetylates ___ ——
A

acetylsalicylic

inhibits

Ser 530

23
Q

flubriprofen ____ aspirin channel and acetylates ___ protein

A

blocks

Ser

24
Q

low dose of aspirin (reduces or increases?) heart attack risk, (inhibits or stimulates?) platelet aggregation by causing enucleated cells, __ days lifetime ,(can or cannot?) resynthesize enzyme

A

reduces

inhibits

10

Cannot

25
Q

Some NSAIDs

  • ____
  • _____
  • ____
  • ____
  • _____
  • ______
A

aspirin

acetaminophen

indomethacin

naproxen

phenylbutazobone

flubriprofen

26
Q

VIOXX

-2 PHGS isoforms (____,____)

A

COX1,COX 2

27
Q

ASPIRIN can’t induce GIT ulceration

T/F

A

F

It can

28
Q

ESKIMOS

  • ____ results of CVS disease despite the fat that they eat a lot of ___
  • they are healthy because they eat —-
  • reduce cholesterol , leukotriene and PG levels
A

Low

fat

fish

29
Q

Effect of cortisol on eicosanoids

A

Inhibits it

30
Q

Eicosanoids regulate blood ______ and induct blood ___

A

Pressure

Clotting

31
Q

Eicosanoids mediate production of ____ and ____

A

Pain and fever

32
Q

Eicosanoids has no reproductive function

T/F

A

F

33
Q

Eicosanoids play no role in the sleep wake cycle

T/F

A

F

34
Q

Eicosanoids causes egress of T lymphocytes

T/F

A

T

35
Q

The prostaglandin parent compound is the _____

A

Prostanoic acid

36
Q

First 3 prostaglandins to be identified

A

E1

E2

F2a

37
Q

Aspirin inhibits ____ enzyme

A

PGH synthase

38
Q

COX 1 is constitutively expressed in ___ tissue include the _____
-COX2 is only seen in ____ tissues and expressed in response to ____

A

most; GIT mucosa

certain; thyroid

39
Q

COX__ is expressed in response to inflammatory stimuli

A

2

40
Q

COX __ is the target for acetaminophen

A

3

41
Q

2 examples of COX2 inhibitors

A

Vioxx (Rofecoxib)

Celecoxib (Celebrex)

42
Q

Prostaglandin ___ is the most potent endogenous sleep promoting substance

A

D2

43
Q

For arachidonic acid to be converted to prostaglandin, it needs to undergo _____

A

Cyclization

Bch 204 (14 decks)

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