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Immunology > E1-Complement System > Flashcards

E1-Complement System Flashcards

1
Q

What two antibodies trigger the CLASSICAL complement system?

A

IgG, IgM

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2
Q

What crazy things can spark the ALTERNATE complement system?

A

Bee, snake venom

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3
Q

What are the three sequential steps of the complement system?

A

RAM 1. Recognition Unit 2. Activation Unit 3. Membrane Attack Unit

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4
Q

What is the name of the recognition complex? How many molecules are involved? What are their names?

A

C1…Its a TRImolecular Complex and they are C1q, C1r, and C1s

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5
Q

Which portion of the immunoglobulin does C1q bind to to start the Recognition? What are the ONLY two Ig’s that C1q can bind to?

A

the FC site of the Ig!! (Remember the Fab is on the tops of the Y and they are on the bacterium!!)…C1q can only bind to IgG and IgM

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6
Q

What does C1q do to C1r?

A

C1q ACTIVATES C1r

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7
Q

What does C1r do to C1s?

A

C1r ACTIVATES C1s

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8
Q

What does C1s activate? What is formed?

A

C4 and then C2…A BIMOLECULAR complex is formed (C4-C2

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9
Q

What is the first step of the Activation Unit?

A

the C4-C2 complex binds to the bacterium

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10
Q

What does C4-C2 activate? What is C4-C2’s nickname?

A

C3…“C3 Convertase”

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11
Q

What does C3 convertase (C4-C2) split C3 into? Which one is larger?

A

Splits C3 into the smAller C3a, and the larBger C3b

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12
Q

What does C3a biochemically function as?

A

an Ana-phylac-toxin (ANAPHYLAXSIS?!)

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13
Q

What are the two complement components that act as ANA-PHYLAC-TOXINs?

A

C3a and C5a

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14
Q

What do anaphylactoxins do with mast cells?

A

Degranulates them and releases histamine

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15
Q

What cause the release of hydrolytic enzymes from PMNs?

A

Anaphylactoxins

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16
Q

What do anaphylactoxins do to smooth muscle?

A

make it contract!

17
Q

Since C3a goes off and does its thing, what is the fate of C3b?

A

C3b binds to C4-C2 to make a TRIMOLECULAR C4-C2-C3b complex!

18
Q

What is the nickname for the trimolecular complex of C4-C2-C3b? hint it has to do with the next step!

A

C5 convertase!

19
Q

What is the result of C3b’s second role of generating numerous sites on the target cell surface?

A

the Immune Adherence Phenomenon!

20
Q

What does C5 convertase split C5 into? Which one is small? Which one is large?

A

smAller C5a, and larBger C5b.. REALLY similar story to C3!

21
Q

What is the major role of C5b?

A

the focal point for MAC!

22
Q

What is the first step of the MAC?

A

C5b fuses with C6,C7,C8 to make a tetra molecular complex C5-C6-C7-C8 which catylizes C9!

23
Q

What is the product of C9 activation?

A

Poly C9 aka Tetra C9

24
Q

What ions are involved in the membrane attack unit?

A

Na and H20 rush in, K out (all w/ [ ] gradients.

Immunology (10 decks)

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