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Pharm Test 2 > Drugs for Allergic Rhinitis (week 5) > Flashcards

Drugs for Allergic Rhinitis (week 5) Flashcards

1
Q

What is the MOA of Intranasal Glucocorticoids?

A

Acts on cells and mediators of inflammation

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2
Q

What are intranasal Glucocorticoids used for?

A

Prevention & treatment of seasonal and perennial rhinitis

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3
Q

What are some adverse effects of Intranasal Glucocorticoids?

A

Drying of nasal mucosa
Sore throat
Adrenal Insufficiency

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4
Q

Name a First-generation H1 receptor antagonist

A

Diphenhydramine (Benadryl)

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5
Q

What is the MOA of Diphenhydramine (Benadryl)?

A

Antagonizes the effects on histamines at H1-receptor sites

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6
Q

What is Diphenhydramine (Benadryl) used for?

A

Hypersensitivity reactions
Motion Sickness
Insomnia

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7
Q

What can Diphenhydramine (Benadryl) do?

A

Cross the blood brain barrier

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8
Q

Name a Second Generation H1 Receptor Antagonist

A

Fexofenadine (Allegra)

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9
Q

What is the MOA of Fexofinadine (Allegra)?

A

Antagonizes the effects of histamine at peripheral H1 receptors

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10
Q

What is Fexofenadine (Allegra) used for?

A

Relief of symptoms of seasonal allergic rhinitis

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11
Q

What are some adverse effects of Fexofinadine (Allegra)?

A

Headache
Dizziness
Impaired Renal Function

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12
Q

What can Fexofinadine (Allegra) interact with?

A

Magnesium and aluminum-containing antacid

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13
Q

What comes second in treatment to Glucocorticoids?

A

Intranasal Cromolyn Sodium

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14
Q

What is the MOA of Intranasal Cromolyn Sodium?

A

Suppresses release of histamine and other inflammatory mediators from mast cells

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15
Q

What is Intranasal Cromolyn Sodium used for?

A

Allergic Rhinitis Prophylaxis

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16
Q

What are some precautions with Intranasal Cromolyn Sodium?

A

Do not use to treat sinus infection, asthma, or URI

17
Q

Name a Sympathomimetic

A

Pseudoephedrine (Sudafed)

18
Q

What is the MOA of Psuedoephedrine (Sudafed)?

A

Stimulated alpha- & beta- adrenergic receptors

Produces Vasoconstriction

19
Q

What is the use of Psuedoephedrine (Sudafed)?

A

Temporary relief of symptoms associated with acute viral URI

20
Q

What are some adverse effects of Psuedoephedrine (Sudafed)?

A 
Anxiety
Palpitations
HTN
Insomnia 
AFib
MI
PVC
21
Q

What are some contraindications of Psuedoephedrine (Sudafed)?

A

Hypersensitivity to sympathetic amines
Severe HTN
Severe CAD

22
Q

What drug can be used to make Meth?

23
Q

Name a Nasal Spray Decongestant

A

Oxymetazoline (Afrin)

24
Q

What is the MOA of Oxymetazoline (Afrin)?

A

Acts directly on alpha 2 receptors to produce vasoconstriction

Pharm Test 2 (18 decks)

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