Aminoglycosides, Sulfonamides, Fluroquinolones (week 6) Flashcards
Name an aminoglycoside.
Gentamicin
What is Gentamicin used for?
Serious aerobic gram-negative infections in combo with Vancouvers or beta-lactam
What is the MOA of Gentamicin?
Inhibits protein synthesis in bacteria at level 3OS ribosome
Bactericidal
What are some adverse reactions for Gentamicin?
Decreased appetite
Nausea
Vomiting
Paint at injection site
Ataxia
Vertigo
What should you assess before administering Gentamicin?
Monitor serum creatinine/BUN
PMH of renal impairment
When should you reduce the dose with Gentamicin?
With renal impairment
What should you evaluate for after administering Gentamicin?
Onset of Tinnitus
Name a Sulfonamide
Trimethoporim-Sulfamethaxazole
What is Trimethoprim-Sulfamethoxazole used for?
Bronchitis
Prevention of PCP in HIV positive patients
What is the MOA of Trimethoprim-Sulfamethoxazole?
Combination inhibits the metabolism of folic acid in bacteria at two different points
Bacteriostatic
What are some common adverse effects of Trimethoprim-Sulfamethoxazole?
Nausea
Vomiting
Rash
Hyperkalemia
Hypokalemia
Stevens-Johnson syndrome
Name a Fluoroquinolone
Ciprofloxacin
What is Ciprofloxacin used for?
Gram-negative infections and some gram-positive organisms
What is the MOA of Ciprofloxacin
Inhibits bacterial DNA synthesis by inhibiting DNA enzyme
Bactericidal
What are the adverse effects of Ciprofloxacin?
Diarrhea
Nausea
Headache
Black box warning - tendinitis, tendon rupture, peripheral neuropathy
