Drugs Flashcards
Erythroppoietic stimulating agen
epoetin
Antifibrinolytics
Epsilon-aminocaproic acid (EACA), Tranexamic acid, Aprotinin (has increase in thrombotic complications)
EACA
Epsilon-aminocaproic acid, an antifibrinolytic
Tranexamic acid
an antifibrinolytic drug
Aprotinin
an antifibrinolytic drug, has increase in thrombotic complications
Reversal agents for drugs (warfarin and heparin)
vitamin K and protamine
DDAVP
drug used in vwF disease to stimulate the release of vWF from endothelial cells. Can also be given for mild hemophilia and aspirin therapy. Promotes hemostasis
Warfarin also known as
coumadin and jantoven
Warfarin what it does
it binds one of the enzymes that uses vitamin K to make coagulation factors, clotting mechanisms are inhibited and it takes longer to clot
Protamine
Protamine sulfate. reverses the effects of heparin in cases of overdoes or surgery/bleeding patients. given by IV
Biochemical changes in blood over time
during storage RBCs undergo biochemical changes called “storage lesions” increase in plasma Hgb, and K+. decrease in pH, ATP, 2,3 DPG(function)
Total Blood Volume
7-8% of body weight. weight, as a rule we typically use 75mL/kg, however infants (108) newborn infant (87) male (66) female (60)
Conversions
1 Liter = 2 Pints(about, not exact) 1 pint = .47 liters
Blood administration venous access gauge
adult= 18-20 gauge needle child: 22-24 gauge needle
Blood administration filters
All blood components must be filtered using a standard filter (170-260 microns)
