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Deferrals Flashcards

1
Q

Double red cell apheresis

A

16 weeks deferral post donation

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2
Q

Been in juvenile detention, lockup fail or prison for more than 72 consecutive hours

A

12 months deferral

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3
Q

Did you spend time that adds up to 5 years or more in the united kingdom between 1980-1996

A

permanent deferral

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4
Q

Did you spend time that adds up to 5 years or more in certain european countries or had a blood transfusion there between 1980 and present?

A

permanent deferral

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5
Q

Maximum hgb/hct for red cell unit apheresis donation

A

20g/dl or 60% hct

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6
Q

Maximum hgb/hct for plateletpheresis, plasmapheresis, or leukapheresis

A

18 g/dl or 54% hct

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7
Q

Donating rbc apheresis, hgb/hct level

A

minimum 13.3 g/dl or 40% hct

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8
Q

IV drug user for nonprescribed drugs

A

permanent deferral

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9
Q

donor is prostitute

A

permanent deferral

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10
Q

donor hired a prostitute

A

1 year deferral

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11
Q

MSM

A

1 year deferral

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12
Q

HIV window period for NAT

A

9 days

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13
Q

HCV window period for NAT

A

8 days

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14
Q

HCV window period EIA

A

70 day window

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15
Q

MP-NAT and WNV/ZIKA

A

low viral titers can be missed with mini-pooled testing, each sample must be tested individually so positive test is not missed. ID-NAT

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16
Q

ID-NAT

A

individual NAT

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17
Q

postive with EIA or Chlia-first time

A

recorded as initially reactive- must be repeated, upon repeat positive-confirmed through other testing platform/different manufacturer if available

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18
Q

anti-HCV test positive first time

A

confirmatory testing is HCV NAT or 2nd manufacturers EIA/ChLIA assay

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19
Q

HIV-1 antibody positive first time

A

confirmatory testing is Western blot or immunofluorescence assay

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20
Q

HIV-2 positive

A

confirmatory testing additional anti-HIV-2 supplemental assay required

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21
Q

T. cruzii positve antibody test

A

confirmatory test done by recombinant antigen based immunoblot assay.

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22
Q

Anti-Hbc positive test first time

A

deferall not necessary 2 independent tests are positve- then permanent deferral, some donor centers make deferral after 1st positive, this is not required.

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23
Q

When EIA test is positive

A

must repeat in duplicate if both duplicates are negative- considered negative, if either of these is positive this is considered a positive for this unit, unit discarded, donor indefintely deferred.

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24
Q

How many infectious disease are mandatory for testing? what are they?

A
  1. HIV, HCV, HBV, HTLV, WNV, ZIKA, T. cruzii, syphilis
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25
Q

How many of the 8 mandatory tests have an EIA/Chlia test? Which ones?

A
  1. anti-HIV 1/2, HBsag, anti-HBc, anti-HCV, HTLV 1/12, T. cruzii antibody
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26
Q

confirmatory testing of T. cruzii, positive

A

antibody positive needs to be confirmed by recombinant antigen-based immunoblot assay.

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27
Q

most common viral transmission agent via transfusion

A

HBV

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28
Q

Permanent deferral for risk associated with HIV infection (3)

A

1.Prostitution of self 2. injection of drugs into system-non-prescribed 3. previous positive results for HIV test

29
Q

testing for HBsag, anti-HCV positive, followed by positive confirmatory testing

A

permanent deferral of donor

30
Q

anti-HBc positive 2x

A

permanent deferral

31
Q

lived with someone with hepatitis

A

deferral for 12 months-from time living with individual ceases.

32
Q

Deferral for positive WNV

A

deferred 120 days

33
Q

Deferral positive for Zika

A

deferred 120 days

34
Q

3 year deferral for malarial risks: (2)

A
  1. lived for combined more than 5 years in malarial endemic area 2. was symptomatic for malaria-since last symtoms
35
Q

1 year deferral for malarial risks

A

If prospective donor does not live in endemic country, but visited an endemic country, never developed malarial symptoms, one year from date returned to non endemic area.- must be in endemic area for more than 24 hours (not drive through area)

36
Q

Ever positve for Chaga’s or Babesia

A

permanent deferral

37
Q

Permanent deferral risk factors CJD (8)

A
  1. dura mater graft 2. realative with CJD 3. human pituitary growth hormone 4. 3 months in UK 1980-1996, 5.in military in europe 1980-1996 6. received a transfusion in UK or France 1980-present 7. received bovine insulin injection sourced from UK or other countries with BSE 8. Spent time that adds up to 5 years or more in Europe from 1980-present
38
Q

Measles deferral

A

2 week

39
Q

Mumps deferral

A

2 week

40
Q

oral polio

A

2 week

41
Q

oral typhoid

A

2 week

42
Q

yellow fever

A

2 week

43
Q

rubella

A

4 week

44
Q

VZV

A

4 week

45
Q

Rubeolla

A

2 week

46
Q

History of hematological malignancy

A

donor permanently deferred

47
Q

History of solid organ tumor

A

deferred until clinically cured (1-5 years depending)

48
Q

isotretinoin

A

one month deferral

49
Q

finasteride

A

one month deferral

50
Q

dutasteride

A

six month deferral

51
Q

acitretin

A

three year deferral

52
Q

etretinate

A

permanent deferral

53
Q

bovine or human growth hormone from pituitary gland

A

permanently deferred

54
Q

clopideogrel

A

2 weeks deferral -if for platelets

55
Q

ticlopidine

A

2 weeks deferral- if for platelets

56
Q

aspirin

A

48 hours deferral

57
Q

warfarin, heparin, anticoagulants

A

termporarily deferred, causes poor efficacy of plasma component and increased risk to donor

58
Q

Female donor post delivery

A

6 week deferral after delivery

59
Q

apheresis platelet- single unit

A

2 day deferral post donation, no more than 2/7days or 24/12 months

60
Q

apheresis platelet- double or triple unit

A

7 days in between donations

61
Q

occasional plasmapheresis donors interval, maximum donations

A

can donate once in 4 weeks, max 13 donations per year, maximum 12L in 12 months.

62
Q

frequent plasmapheresis donors

A

at least 48 hours between two procedures, no more than 2/7 days (same as apheresis platelets).

63
Q

Maximum RBC loss in plasmapheresis

A

cannot lose more than 25 mL/week

64
Q

Testing quantities for frequent plasma donation

A

must be tested for total protein and serum protein electrophoresis OR quantitative immunglobulins, results need to be normal.

65
Q

interval between WB donations

A

8 weeks

66
Q

neutrophil stimulation of donors for granulocytes, drugs

A

G-CSF, and dexamethasone (steroids) are at maximum 12 hours after given drugs

67
Q

requirements for granulocytes donors-

A

must aborh match recipient, donor cannot be pregnant as G-CSF not approved for pregnancy, cannot have hemoglobinopathies, no history of allergy to steroids or starch (HES), shoul dnot have hypertension, diabetes, GI ulcers, tuberculosis or fungal infections- poor reaction with steroid treatment.

68
Q

deferral after granulocytes donation

A

8 weeks between WB donation- 2 days between additional granulocytes donation no more than 2/7 days

SBB (31 decks)

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