Deferrals Flashcards
Double red cell apheresis
16 weeks deferral post donation
Been in juvenile detention, lockup fail or prison for more than 72 consecutive hours
12 months deferral
Did you spend time that adds up to 5 years or more in the united kingdom between 1980-1996
permanent deferral
Did you spend time that adds up to 5 years or more in certain european countries or had a blood transfusion there between 1980 and present?
permanent deferral
Maximum hgb/hct for red cell unit apheresis donation
20g/dl or 60% hct
Maximum hgb/hct for plateletpheresis, plasmapheresis, or leukapheresis
18 g/dl or 54% hct
Donating rbc apheresis, hgb/hct level
minimum 13.3 g/dl or 40% hct
IV drug user for nonprescribed drugs
permanent deferral
donor is prostitute
permanent deferral
donor hired a prostitute
1 year deferral
MSM
1 year deferral
HIV window period for NAT
9 days
HCV window period for NAT
8 days
HCV window period EIA
70 day window
MP-NAT and WNV/ZIKA
low viral titers can be missed with mini-pooled testing, each sample must be tested individually so positive test is not missed. ID-NAT
ID-NAT
individual NAT
postive with EIA or Chlia-first time
recorded as initially reactive- must be repeated, upon repeat positive-confirmed through other testing platform/different manufacturer if available
anti-HCV test positive first time
confirmatory testing is HCV NAT or 2nd manufacturers EIA/ChLIA assay
HIV-1 antibody positive first time
confirmatory testing is Western blot or immunofluorescence assay
HIV-2 positive
confirmatory testing additional anti-HIV-2 supplemental assay required
T. cruzii positve antibody test
confirmatory test done by recombinant antigen based immunoblot assay.
Anti-Hbc positive test first time
deferall not necessary 2 independent tests are positve- then permanent deferral, some donor centers make deferral after 1st positive, this is not required.
When EIA test is positive
must repeat in duplicate if both duplicates are negative- considered negative, if either of these is positive this is considered a positive for this unit, unit discarded, donor indefintely deferred.
How many infectious disease are mandatory for testing? what are they?
- HIV, HCV, HBV, HTLV, WNV, ZIKA, T. cruzii, syphilis
How many of the 8 mandatory tests have an EIA/Chlia test? Which ones?
- anti-HIV 1/2, HBsag, anti-HBc, anti-HCV, HTLV 1/12, T. cruzii antibody
confirmatory testing of T. cruzii, positive
antibody positive needs to be confirmed by recombinant antigen-based immunoblot assay.
most common viral transmission agent via transfusion
HBV
Permanent deferral for risk associated with HIV infection (3)
1.Prostitution of self 2. injection of drugs into system-non-prescribed 3. previous positive results for HIV test
testing for HBsag, anti-HCV positive, followed by positive confirmatory testing
permanent deferral of donor
anti-HBc positive 2x
permanent deferral
lived with someone with hepatitis
deferral for 12 months-from time living with individual ceases.
Deferral for positive WNV
deferred 120 days
Deferral positive for Zika
deferred 120 days
3 year deferral for malarial risks: (2)
- lived for combined more than 5 years in malarial endemic area 2. was symptomatic for malaria-since last symtoms
1 year deferral for malarial risks
If prospective donor does not live in endemic country, but visited an endemic country, never developed malarial symptoms, one year from date returned to non endemic area.- must be in endemic area for more than 24 hours (not drive through area)
Ever positve for Chaga’s or Babesia
permanent deferral
Permanent deferral risk factors CJD (8)
- dura mater graft 2. realative with CJD 3. human pituitary growth hormone 4. 3 months in UK 1980-1996, 5.in military in europe 1980-1996 6. received a transfusion in UK or France 1980-present 7. received bovine insulin injection sourced from UK or other countries with BSE 8. Spent time that adds up to 5 years or more in Europe from 1980-present
Measles deferral
2 week
Mumps deferral
2 week
oral polio
2 week
oral typhoid
2 week
yellow fever
2 week
rubella
4 week
VZV
4 week
Rubeolla
2 week
History of hematological malignancy
donor permanently deferred
History of solid organ tumor
deferred until clinically cured (1-5 years depending)
isotretinoin
one month deferral
finasteride
one month deferral
dutasteride
six month deferral
acitretin
three year deferral
etretinate
permanent deferral
bovine or human growth hormone from pituitary gland
permanently deferred
clopideogrel
2 weeks deferral -if for platelets
ticlopidine
2 weeks deferral- if for platelets
aspirin
48 hours deferral
warfarin, heparin, anticoagulants
termporarily deferred, causes poor efficacy of plasma component and increased risk to donor
Female donor post delivery
6 week deferral after delivery
apheresis platelet- single unit
2 day deferral post donation, no more than 2/7days or 24/12 months
apheresis platelet- double or triple unit
7 days in between donations
occasional plasmapheresis donors interval, maximum donations
can donate once in 4 weeks, max 13 donations per year, maximum 12L in 12 months.
frequent plasmapheresis donors
at least 48 hours between two procedures, no more than 2/7 days (same as apheresis platelets).
Maximum RBC loss in plasmapheresis
cannot lose more than 25 mL/week
Testing quantities for frequent plasma donation
must be tested for total protein and serum protein electrophoresis OR quantitative immunglobulins, results need to be normal.
interval between WB donations
8 weeks
neutrophil stimulation of donors for granulocytes, drugs
G-CSF, and dexamethasone (steroids) are at maximum 12 hours after given drugs
requirements for granulocytes donors-
must aborh match recipient, donor cannot be pregnant as G-CSF not approved for pregnancy, cannot have hemoglobinopathies, no history of allergy to steroids or starch (HES), shoul dnot have hypertension, diabetes, GI ulcers, tuberculosis or fungal infections- poor reaction with steroid treatment.
deferral after granulocytes donation
8 weeks between WB donation- 2 days between additional granulocytes donation no more than 2/7 days
