drugs

Question 1

mechanism of action of PPIs

Answer 1

blocks H+/K+ ATPase (proton pump) via covalent modification

Question 2

mechanism of action of aspirin

Answer 2

irreversibly blocks cyclo-oxygenase (COX 1)

Question 3

mechanism of action of H2 histamine receptor antagonist

Answer 3

competitively blocks H2 cells

Question 4

mechanism of action of Muscarinic receptor antagonists

Answer 4

competitively blocks M1 cells

Question 5

drugs that reduce gastric acid secretion are used in the treatment of what? (4)

Answer 5

peptic ulcer
GORD
Zollinger-ellison syndrome
cushing’s ulcers

Question 6

example of a PPI

Answer 6

omeprazole

anything ending “prazole”

Question 7

how are PPI administered

Answer 7

once daily, orally

Question 8

examples of H2 histamine receptor antagonist

Answer 8

ranitidine
cimetidine
anything ending “-tidine”

Question 9

how are H2 histamine receptor antagonist administered

Answer 9

once/twice daily, orally

Question 10

what are H2 histamine receptor antagonist used in the treatment of

Answer 10

peptic ulcer

reflux oesophagitis

Question 11

Muscarinic receptor antagonists example

Answer 11

pirenzepine

Question 12

what are Muscarinic receptor antagonists used in the treatment of

Answer 12

previously peptic ulcer, now obsolete

Question 13

examples of mucosal strengtheners

Answer 13

sucralfate

bismuth chelate

Question 14

mechanism of action of sucralfate

Answer 14

bind to ulcer base and forms complex with the mucus to provide barrier against acid and pepsin

Question 15

how is sucralfate administered

Answer 15

orally

Question 16

mechanism of action of bismuth chelate

Answer 16

bind to ulcer base and forms complex with the mucus to provide barrier against acid and pepsin

Question 17

what is bismuth chelate used in the treatment of? why?

Answer 17

peptic ulcer

toxic to h.pylori

Question 18

how is bismuth chelate administered

Answer 18

orally in combo with ranitidine