Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hugh's MD2 Foundation > Drugs > Flashcards

Drugs Flashcards

1
Q

What type of drug is nifedipine? Indications? Side effects?

A

Dihydropyridine calcium channel blocker (peripheral vasodilator)

HTN, angina

Peripheral oedema that doesn’t respond to diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

What is the method of action and indication of methotrexate?

A

Inhibition of folic acid

Acute lymphoblastic leukaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is frusemide?

A

Loop diuretic

Acts on the thick ascending limb of loop of Henle

Causes K+ loss due to increased Na+ in collecting duct (actions of aldosterone)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is ototoxic mean?

A

Toxic to the ear - specifically the cochlea or auditory nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which diuretic is used in HTN?

A

Thiazides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What type of drug is amlodipine?

A

Dihydropyridine calcium channel blocker (peripheral vasodilator)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the mechanism of action of metoclopramide?

A

Blocks dopamine receptor (and when given at higher doses) serotinin receptors in the chemoreceptor trigger zone in the CNS

Enhances the activity of ACh in the gut to increase motility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What type of drugs rapamil?

A

Non-dihydropyridine calcium channel blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is Tazocin?

A

A combination of the beta-lactam piperacillin and beta-lactamase inhibitor tazobactam

Commonly indicated in patients with hospitally acquired pneumonia/septicaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is celecoxib?

A

An NSAID used for some arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is novorapid?

A

Fast-acting insulin analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What type of drug is midazolam?

A

A benzodiazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the mechanism of action and effect of benzodiazepines?

A

Potent inhibitor of GABA in the CNS

Antianolytic, sedative, hypnotic, muscle relaxant, antiepileptic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is spirolactone?

A

K-sparring diuretic > aldosterone receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the names of some non-dihydropyridine calcium channel blockers?

A

Verapamil

Diltiazem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What type of drug is diltiazem?

A

Non-dihydropyridine calcium channel blocker

14
Q

What is Fentanyl?

A

Synthetic opioid analgesic

15
Q

What is the triple whammy effect of NSAIDs, diuretics, and ACEIs?

A

NSAIDs block prostaglandin production, prostaglandin provides tonic vasodilation of afferent renal arterioles

ACEI block angiotensin II, which exerts tonic vasoconstriction of efferent arterioles

Diuretics reduce plasma volume and renal plasma flow

= Reduction in GFR = renal damage

17
Q

What is lactulose indicated for?

A

Chronic constipation

Hepatic encephalopathy

19
Q

What is dilantin?

A

Anti-convulsant for management of complex partial seizures and generalised tonic-clonic seizures

20
Q

Which are the centrally acting calcium channel blockers, dihydropyridines or non-dihydropyridines

A

Non-dihydropyridines

21
Q

What is the mechanism of action of calcium channel blockers?

A

Inhibit the slow inward calcium current in cardiac arteriolar muscle cells, reducing contractility, SA activity, AV node conduction and vascular tone

Can be vascularly selective - dihydropyridine CCBs > arteriolar vasodilation > reduce afterload

Or cardiac and vascular selective with negative inotropic and chronotropic properties > used for arrhythmias and angina

23
Q

What is targin?

A

Oxycodone/Naloxone opioid analgesic

Oxycodone is pain relief

Naloxone reduces opioid-induced euphoria & constipation

24
Q

What dose of naloxone is used to reverse opioid overdose? What pharmakinetic factor must be considered?

A

0.4 to 2mg initial, repeated every 2-3mins until reversal (to a maximum of 10mg)

The duration of action of naloxone is shorter than opioids, must monitor patient

25
Q

Which diuretic is used in heart failure?

A

Loop diuretic ie frusemide

26
Q

What type of drug is isosorbide mononitrate?

A

A nitrate used in the treatment of angina

Dilates blood vessels

27
Q

What is the names of some dihydropyridine calcium channel blockers?

A

Nifedipine

Amlodipine

28
Q

How does lactulose treat hepatic encephalopathy?

A

Lactulose helps trap the ammonia (NH3) in the colon. It does this by using gut flora to acidify the colon, transforming the freely diffusible ammonia into ammonium (NH4+) which can no longer diffuse back into the blood.

Hugh's MD2 Foundation (47 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions