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Drug Side Effects Flashcards

1
Q

Flushing

A

niacin, vancomycin (red man syndrome), adenosine, dihydropyridine calcium channel blockers

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2
Q

Coronary artery vasospasm

A

cocaine, amphetamines, triptans, ergotamine

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3
Q

Dilated cardiomyopathy

A

doxorubicin, daunorubicin

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4
Q

Torsades de pointes (prolonged QT)

A

potassium channel blockers (class III), sodium channel blockers (class IA), macrolides, haloperidol, chloroquine, protease inhibitors (ritonavir)

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5
Q

Thrombocytopenia

A

heparin, cimetidine

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6
Q

Agranulocytosis

A

clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone
-think of the C’s + antithyroid drugs

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7
Q

Aplastic anemia

A

chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

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8
Q

Gray baby syndrome

A

chloramphenicol

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9
Q

Hemolysis in G6PD deficiency

A

isoniazid, sulfonamides, primaquine, aspirin (high-dose), ibuprofen, nitrofurantoin, dapsone, fava beans, naphthalene

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10
Q

Thrombosis

A

oral contraceptives

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11
Q

Pulmonary fibrosis

A

amiodarone, bleomycin, busulfan

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12
Q

Cough

A

ace inhibitors

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13
Q

Pseudomembranous colitis

A

clindamycin, amoxicillin/ampicillin

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14
Q

Hepatic necrosis

A

halothane, acetaminophen, valproic acid, amanita phalloides (mushroom toxin)

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15
Q

Hepatitis

A

isoniazid

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16
Q

Tertiary adrenal insufficiency

A

corticosteroid withdrawal

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17
Q

Gynecomastia

A

“Some drugs cause awesome knockers”

Spirinolactone, Digoxin, Cimetidine, Alcohol, Ketoconazole (and estrogens)

18
Q

Hot flashes

A

tamoxifen, clomiphene

19
Q

Hypothyroidism

A

amiodarone, lithium, sulfonamides

20
Q

Gout

A

diuretics (loop and thiazide), niacin, cyclosporine, pyrazinamide

21
Q

Gingival hyperplasia

A

phenytoin, verapamil

22
Q

Osteoporosis

A

corticosteroids, heparin

23
Q

Photosensitivity

A

Tetracycline, amiodarone, sulfonamides

24
Q

Stevens-Johnson syndrome

A

Steve Jobs made APPLE PCS - Allopurinol, Phenytoin, Phenobarbital, Lamotrigine, Ethosuxamide, Penicillin, Carbamazepine, Sulfonamide

25
Q

Drug-induced lupus

A

sulfonamides, hydralazine, isoniazid, procainamide, phenytoin (SHIPP)

26
Q

Tendinitis/cartilage damage

A

fluoroquinolones

27
Q

Interstitial nephritis

A

NSAIDs, furosemide, antibiotics

28
Q

Diabetes insipidus

A

lithium, demeclocycline

29
Q

Fanconi syndrome

A

expired tetracycline

30
Q

Hemorrhagic cystitis

A

cyclophosphamide, ifosfamide

31
Q

Parkinson-like syndrome

A

metaclopramide, antipsychotics, reserpine

32
Q

Cinchonism (dizziness, HA, vision change, tinnitus)

A

quinidine, quinine

33
Q

Seizures

A

bupropion, imipenem/cilastatin, isoniazid, tramadol, metoclopramide, benzos/alcohol withdrawal

34
Q

Tardive dyskinesia

A

antipsychotics, metoclopramide

35
Q

Disulfiram-like rxn

A

metronidazole, certain cephalosporins, procarbazine, first-generation sulfonylureas, disulfiram

36
Q

Nephrotoxicity + Neurotoxicity

A

aminoglycosides, cisplatin, polymixins

37
Q

Nephrotoxicity + Ototoxicity

A

aminoglycosides (streptomycin), vanco, loop diuretics, cisplatin

38
Q

Anticholinergic effects

A

atropine, TCAs, H-1 blockers, low-potency neuroleptics

39
Q

Induce Cyp450 enzymes

A

Coronas, Guiness, and PBRS induce chronic alcoholism - Carbamazepine, Griseofulvin, Phenytoin, Rifampin, St. Johns wort, Chronic alcohol use

40
Q

SE of Phenytoin

A

“Phenytoin Has Given MD’S Frustation” - Peripheral neuropathy, Hirsuitism, Gingival hyperplasia, Megaloblastic anemia, Drug-induced lupus, SJS, Fetal hydantoin syndrome

41
Q

Drugs that can be harmful in sulfa allergy

A

“Sulfa Pills Frequently Cause Terrible Allergy Symptoms” - Sulfasalazine, Probenicid, Furosemide, Celecoxib, Thiazides/TMP-SMX, Acetazolamide, Sulfonylureas

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