Drug Overdose

Question 1

Morphine overdose features?

Answer 1

Reduced responsiveness
Pinpoint pupils
Respiratory depression

Question 2

Treatment for morphine/opiate overdose?

Answer 2

Naloxone

Question 3

Naloxone MoA?

Answer 3

Very strong affinity for mu receptors so outcompetes opiate molecules for binding sites

Question 4

Points of caution with naloxone?

Answer 4

• Very strong affinity for mu receptors so may rapidly induce opiate withdrawal + seizures
• Also has a shorter half-life than opiates, so repeated doses or infusion may be required

Question 5

Antimuscarinic overdose antidote?

atropine, ipratropium, scopolamine/hyoscine, tropicamide

Answer 5

Physostigmine

Question 6

Aspirin overdose antidote?

Answer 6

Sodium bicarbonate

Question 7

Benzodiazepine overdose antidote? (chlordiazepoxide, diazepam, most -epams)

Answer 7

Flumazenil

Question 8

Beta-blocker overdose antidote?

Answer 8

Atropine, glucagon

Question 9

CO poisoning antidote?

Answer 9

Oxygen

Question 10

Digoxin overdose antidote?

Answer 10

Digibind

Question 11

Heparin overdose antidote?

Answer 11

Protamine

Question 12

Iron overdose antidote?

Answer 12

Desferrioxamine

Question 13

Methanol overdose antidote?

Answer 13

Ethanol

Question 14

Paracetamol overdose antidote?

Answer 14

N-acetylcysteine

Question 15

Warfarin overdose antidote?

Answer 15

Vitamin K