Digoxin Flashcards

1
Q

What is Digoxin and where is it extracted from?

A

Positively inotropic cardiac glycoside

Extracted from foxglove Digitalis lanata

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2
Q

What is Digoxin’s MoA?

A

Positive inotrope
1 - Blocks Na/K exchange, increasing intracellular Na
2 - Na/Ca exchange takes place, increasing intracellular Ca
3 - Contractility is increased, AV node delay increased, HR reduced (secondary negative chronotropic effect)

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3
Q

What is Digoxin used for and why?

A

Symptomatic relief in heart failure

  • has been shown to be effective in doing so, without improving mortality
  • but is the only inotrope that doesn’t increase mortality
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