Clostridium Difficile Infection

Question 1

Why is barrier nursing in a side room indicated in C. diff infection but not an appropriate immediate step?

Answer 1

Prevents spread of the organism

- inappropriate as doesn’t treat the patient

Question 2

Co-amoxiclav, clarithromycin, IV/oral vancomycin; which one do you use and why?

Answer 2

Oral vancomycin - vancomycin is useful in treating C.diff but IV vancomycin cannot cross bowel wall so oral is necessary

Co-amoxiclav isn’t used to treat C.diff and can cause it
Clarithromycin isn’t used to treat C.diff

Question 3

How does omeprazole affect risk of C.diff infection and why?

Answer 3

Increases risk by reducing acidity of the bowel contents, prolonging C.diff survival

Question 4

What other drug can be used to treat C.diff if patient is allergic/intolerant to oral vancomycin?

Answer 4

Oral metronidazole