Drug monitoring lecture

Question 1

budenoside in kid what do you need to measure

Answer 1

height and weight if prolonged use on intransal steriods

Question 2

can you give aminoglycosides in myasthenia gravis

Answer 2

no

Question 3

do thiazides cause impotence

Answer 3

yes

Question 4

BB not controlling angina what next

Answer 4

CCB - long acting dihydro - amlodipine

Question 5

major bleed on warfarin with INR lowish what do you do

Answer 5

Major bleeding - stop warfarin, give intravenous vitamin K 5mg, prothrombin complex concentrate

Question 6

tx for heart valves both mechnaical and bioprosthetic - how do they differ

Answer 6

bioprosthetic: aspirin
mechanical: warfarin + aspirin

Question 7

most approapitae montioring in first 6 hours for benift of fluid hydration with NaCl after being dehydrated

Answer 7

blood pressure

Question 8

what is best way of monitoring adverse effect with lithoum

Answer 8

UandE

Question 9

most appropriate montioring for HRT to measure adverse effect

Answer 9

BP - can rise in HRT

Question 10

furosemide what do you need to measure of the beneficial effects

Answer 10

weight

Question 11

most importantn adverse affect to make people aware of with apixaban

Answer 11

bruising and bleeding

Question 12

benficial monitor of BB in af

Answer 12

heart rate as control AF

Question 13

what do you need to monitor before amiodarone tx

Answer 13

potassium - hypokalameia is a caution with amiodarone and should be corrected before

Question 14

do SSRI need monitoring within first 2 motnhs

Answer 14

nope - no routine stuff

Question 15

urinary sepsis pt what should be montior to see the benficial effects of abx

Answer 15

resolution of acute sx over 72hour period s

Question 16

BB for AF what are you going to measure for benefical effects

Answer 16

HF

Question 17

ACEI in hf what are you gonn measure for benficial effects to show tx is working

Answer 17

improved exercise tolerance

Question 18

what should your INR be on the day of surgery

Answer 18

1.5

Question 19

what need to monitored for lithim at 6 motnhs

Answer 19

TFT
U&E

Question 20

prior to treatment what should be measured prior to start

Answer 20

TFT, U&E prior to treatment
Lithium levels weekly until stabilised then every 3 months

Question 21

valporate before treatment what two thing need to be tested and then what one parameter every 6 months

Answer 21

LFT, FBC before treatment
LFT ‘periodically’ during first 6 months

Question 22

with glitazones what do you need to measure

Answer 22

LFT

Question 23

statins what do you need to measure

Answer 23

LFTs at baseline, 3 months and 12 months

Question 24

with ACEi do you need to monitor

Answer 24

U&E prior to treatment
U&E after increasing dose
U&E at least annually

Question 25

amiodarone what do you measure every 6 motnhs

Answer 25

TFT, LFT every 6 months

Question 26

amiodarone what needs to be looked at prior to treatment

Answer 26

TFT, LFT, U&E, CXR prior to treatment

Question 27

methotrexate how often do you need to monitor - pre starting - ewekly until stabalised then every 2-3 months of what

Answer 27

FBC, LFT, U&E

Question 28

azathiopurine what needs to be monitored

Answer 28

FBC, LFT before treatment FBC weekly for the first 4 weeks FBC, LFT every 3 months

Question 29

Phenytoin levels do not need to be monitored routinely but trough levels, immediately before dose should be checked if:

Answer 29

adjustment of phenytoin dose suspected toxicity detection of non-adherence to the prescribed medication

Question 30

when do you measure lithium post dose

Answer 30

12 hours post dose

Question 31

when do you measure ciclosporin dose

Answer 31

trough levels immediately before dose