Drug monitoring lecture Flashcards
budenoside in kid what do you need to measure
height and weight if prolonged use on intransal steriods
can you give aminoglycosides in myasthenia gravis
no
do thiazides cause impotence
yes
BB not controlling angina what next
CCB - long acting dihydro - amlodipine
major bleed on warfarin with INR lowish what do you do
Major bleeding - stop warfarin, give intravenous vitamin K 5mg, prothrombin complex concentrate
tx for heart valves both mechnaical and bioprosthetic - how do they differ
bioprosthetic: aspirin
mechanical: warfarin + aspirin
most approapitae montioring in first 6 hours for benift of fluid hydration with NaCl after being dehydrated
blood pressure
what is best way of monitoring adverse effect with lithoum
UandE
most appropriate montioring for HRT to measure adverse effect
BP - can rise in HRT
furosemide what do you need to measure of the beneficial effects
weight
most importantn adverse affect to make people aware of with apixaban
bruising and bleeding
benficial monitor of BB in af
heart rate as control AF
what do you need to monitor before amiodarone tx
potassium - hypokalameia is a caution with amiodarone and should be corrected before
do SSRI need monitoring within first 2 motnhs
nope - no routine stuff
urinary sepsis pt what should be montior to see the benficial effects of abx
resolution of acute sx over 72hour period s
BB for AF what are you going to measure for benefical effects
HF
ACEI in hf what are you gonn measure for benficial effects to show tx is working
improved exercise tolerance
what should your INR be on the day of surgery
1.5
what need to monitored for lithim at 6 motnhs
TFT
U&E
prior to treatment what should be measured prior to start
TFT, U&E prior to treatment
Lithium levels weekly until stabilised then every 3 months
valporate before treatment what two thing need to be tested and then what one parameter every 6 months
LFT, FBC before treatment
LFT ‘periodically’ during first 6 months
with glitazones what do you need to measure
LFT
statins what do you need to measure
LFTs at baseline, 3 months and 12 months
with ACEi do you need to monitor
U&E prior to treatment
U&E after increasing dose
U&E at least annually
amiodarone what do you measure every 6 motnhs
TFT, LFT every 6 months
amiodarone what needs to be looked at prior to treatment
TFT, LFT, U&E, CXR prior to treatment
methotrexate how often do you need to monitor - pre starting - ewekly until stabalised then every 2-3 months of what
FBC, LFT, U&E
azathiopurine what needs to be monitored
FBC, LFT before treatment
FBC weekly for the first 4 weeks
FBC, LFT every 3 months
Phenytoin levels do not need to be monitored routinely but trough levels, immediately before dose should be checked if:
adjustment of phenytoin dose
suspected toxicity
detection of non-adherence to the prescribed medication
when do you measure lithium post dose
12 hours post dose
when do you measure ciclosporin dose
trough levels immediately before dose
