Drug Interactions

Question 1

How does albumin affect drug distribution?

Answer 1

• low albumin can cause increased free fractions of drugs
• toxic effects are more likely to occur due to albumin being binding/carrier protein for most drugs

Question 2

What is a the main concern with long term use of PPI’s?

Answer 2

Low B12

Question 3

Dairy and antibiotics (Abx)

Answer 3

cheltion reaction occurs, do not consume dairy near time of taking antibiotics
- calcium binds to antibiotics

Question 4

cytochrom p450/furanocoumarin

Answer 4

furanocoumarin inhibits the enzyme cytochrome p450 which is used in liver to break down drugs
- can lead to toxis effects of drugs at lower amounts
- found in grapefruit and other citrus fruits

Question 5

Long term issues of corticosteroids

Answer 5

Calcium and Vit D levels

Question 6

Potassium sparing/depleting diuretics

Answer 6

• Lasix: monitor K+ levels (some Mg, Na and phosphorus depletion as well)

Question 7

What is our education for coumadin/warfarin?

Answer 7

• supplement with vitamin K
• blood thinner

Question 8

How should we adjust a diet intake for someone of MAOI?

Answer 8

avoid foods high in tyramine
- aged meats
- aged cheese
- soy

Question 9

things to watch with long term metformin use

Answer 9

• monitor B12
• not compatible with cythroid (hypothyroid medication); makes both medications inactive when taken together

Question 10

Antibiotic associated diarhhea (AAD) recs

Answer 10

• fluids
• bland foods
• probiotics/prebiotics
• spread out antibiotic and calcium intake (binds to antibiotics)