Drug Delivery Systems

Question 1

3 key factors that determine the drug delivery system used

Answer 1

1. Dose of drug being given
2. Frequency of administration
3. Timing of administration

Question 2

Suspensions are

Answer 2

dispersions of coarse drug particles in a liquid phase

Question 3

Enteric Coated Tablets

Answer 3

Delay the integration of the tablet until it reaches the small intestine

Question 4

GTN

Answer 4

Angina, Glycerol Trinitrate

Question 5

Parenteral Preparations

Answer 5

Intramuscular injections (progesterone for contraception)

Question 6

Surgical Implants

Answer 6

Progesterone Contraception (rod)

Question 7

Pro-drugs

Answer 7

Synthesized inactive derivatives of an active drug which requires to be metabolically activated after administration
(avoids degradation in the gut)

Question 8

Buccal and Sublingual are ideal for…

Answer 8

Bypassing first pass metabolism

Question 9

First pass metabolism (pre-systemic metabolism)

Answer 9

Phenomenon of drug metabolism when the concentration of a drug is greatly reduced before it reaches systemic circulation

Question 10

Injection-based drug delivery

Answer 10

Good for bypassing first pass metabolism and also for drugs with a short half-life

Question 11

Subcutaneous is good to use because….

Answer 11

bypasses venous access

Question 12

Transdermal

Answer 12

Drug crosses the skin surface by percutaneous absorption and goes into systemic circulation
examples: Nicotine, opiates, contraception

Question 13

Inhalation

Answer 13

Medication administered via a pressurised aerosol. Good for treating lung disease such as asthma

Question 14

Advantages of Inhalation

Answer 14

Drug delivered directly to site of actions, Rapid effect, Small doses required

Question 15

Monoclonal Antibodies (mABs)

Answer 15

Act directly when binding to a cancer specific antigen and induce immunological response to cancer cells

Question 16

Liposomal Drug Delivery Advantages

Answer 16

Exhibit reduced toxicities and enhanced efficiency

Question 17

Nanoparticle Based drug delivery

Answer 17

The drug can be targeted to a precise location which would make the drug much more effective and reduce the chances of possible side effects

Question 18

Nano-erythrosomes

Answer 18

Releases erythrocytes that can carry proteins, enzymes and macromolecules

Question 19

Intramuscular Injection

Answer 19

Injection into the muscle mass. Allows a sustained duration of action (months)