Chronic Inflammation

Question 1

cell population in inflammation is mostly

Answer 1

lymphocytes
plasma cells
macrophages
fibroblasts

Question 2

clinical presentations can be

Answer 2

loss of function

malaise and weight loss

Question 3

when do we see chronic inflammation?

Answer 3

arising from acute inflammation

arising as a primary lesion

Question 4

Granulation tissues us a characteristic of…

Answer 4

organisation

results in healing and repair

leads to fibrosis and formation of a scar

Question 5

Granulation tissue mechanism

Answer 5

capillaries grow into inflammatory mass

access plasma proteins

macrophages move from blood to tissue

fibroblasts lay down collagen to repair damaged tissue

collagen replaces inflammatory exudate

Question 6

fibroblasts lay down ……….. to repair damaged tissue

Answer 6

collagen

Question 7

macrophages move from

Answer 7

blood to tissue

Question 8

collagen replaces

Answer 8

inflammatory exudate

Question 9

Products of granulation tissue

Answer 9

fibrous tissue (scar)

fibrosis as a problem

chronic inflammation

Question 10

fibrosis

Answer 10

the formation of excess fibrous connective tissue in an organ or tissue to repair

Question 11

autoantibodies directed against own cell components (AUTOANTIGENS)

disease is called?

Answer 11

autoimmune disease

Question 12

tissue components

Answer 12

granulation tissue

collagen

Question 13

two types of lymphocyte

Answer 13

T cell

B cell

Question 14

Lymphocyte 2 main functions

Answer 14

immune response

immune memory

Question 15

Lymphocytes are part of the ………… system

Answer 15

immune

Question 16

Plasma cell is a

Answer 16

differentiated B cell

Question 17

plasma cells produces

Answer 17

antibodies

Question 18

B cells differentiate into

Answer 18

plasma cells

Question 19

T cells produce

Answer 19

cytokines

interferons

Question 20

Cytokines attract, hold and activate

Answer 20

macrophages

Question 21

interferons have

Answer 21

antiviral effects

Question 22

NK cells destroy

Answer 22

antigens and cells

Question 23

Macrophage (phagocyte)role in the immune system is an

Answer 23

antigen presenting cell

Question 24

Macrophages remove

Answer 24

debris

Question 25

macrophages take over from

Answer 25

neutrophils

Question 26

Fibroblasts make and assemble

Answer 26

collagen

Question 27

Granulomatous inflammation is stimulated by

Answer 27

indigestible antigen

body cannot get rid of it

Question 28

Granulomas

Answer 28

aggregates of epithelioid macrophages in tissues

Question 29

A giant cell

Answer 29

is a mass formed by the union of several distinct cells (usually macrophages), often forming a granuloma

Question 30

4 types of giant cells

Answer 30

langhans
foreign body
silicone
warthin-finkeldy

Question 31

Infectious granulomatous diseases

Answer 31

tuberculosis
leprosy
syphilis

Question 32

sequence of events

Answer 32

acute inflammation

organisation

granulation tissue

macrophages remove debris