Antimicrobial Chemotherapy

Question 1

bactericidal

Answer 1

antimicrobial that kills bacteria

penicillin’s

Question 2

bacteriostatic

Answer 2

antimicrobial inhibits growth of bacteria

Question 3

sensitive

Answer 3

if organism is able to be inhibited or killed by the antimicrobial

Question 4

MBC

Answer 4

Minimal bactericidal concentration

Question 5

Minimal bactericidal concentration

Answer 5

minimum concentration of antimicrobial needed to kill a given organism

Question 6

MIC

Answer 6

Minimal inhibitory concentration

Question 7

Minimal inhibitory concentration

Answer 7

minimum concentration of antimicrobial needed to inhibit growth of a given organism

Question 8

parenteral

Answer 8

administered intravenously

Question 9

Antibiotics may inhibit/ kill bacteria in three ways:

Answer 9

inhibition of cell wall synthesis

inhibition of nucleic acid synthesis

inhibition of protein synthesis

Question 10

Antibiotics that inhibit cell wall synthesis

Answer 10

Beta lactams

penicillin and cephalosporins

Question 11

beta lactams

Answer 11

disrupt peptidoglycan synthesis by inhibiting penicillin binding proteins PBPs!

Question 12

Glycopeptides only act on

Answer 12

gram positive organisms

Question 13

Glycopeptides are administered

Answer 13

by IV

Question 14

Glycopeptides act on cell wall synthesis before

Answer 14

beta lactams

inhibiting assembly of peptidoglycan precursor

Question 15

Antibiotic that inhibit protein synthesis

Answer 15

aminoglycosides

macrolides

tetracycline

oxazolidinones

cyclic lipopeptide

Question 16

E.coli is gram….

Answer 16

negative

Question 17

inhibitors of nucleic acid synthesis involve the inhibition of different steps in

Answer 17

purine synthesis

Question 18

Inhibitors of nucleic acid synthesis

Answer 18

co-trimoxazole

fluoroquinolones

Question 19

Trimethoprim

Answer 19

treats UTI

Question 20

streptococci is always resistant to…

Answer 20

aminoglycosides

Question 21

Gram negative organisms are always resistant to

Answer 21

vancomycin

Question 22

E.coli is resistant to

Answer 22

ampicillin

Question 23

two ways in which resistance is acquired

Answer 23

spontaneous

spread of resistance

Question 24

beta lactamases are bacterial enzymes which cleave the…

Answer 24

beta lactam ring of the antibiotic

they thus render it inactive

Question 25

most staphylococcus aureus produce

Answer 25

beta lactamase

Question 26

two ways to combat beta lactamase

Answer 26

add another antibiotic modify the antibiotic

Question 27

Flucloxacillin is

Answer 27

beta lactamase resistant

Question 28

Flucloxacillin can treat

Answer 28

staphylococcal infections

Question 29

benzyl penicillin can treat

Answer 29

gram positive organisms

Question 30

amoxicillin, ampicillin treat

Answer 30

gram negative

Question 31

co-amoxiclav

Answer 31

beta lactamase producing coliforms

Question 32

aminoglycosides treat

Answer 32

gram negative organisms

Question 33

Gentamicin

Answer 33

cheap and most commonly used treated gram negative e.coli

Question 34

Marcolides treat

Answer 34

gram positive

Question 35

Quinolones treat nearly all

Answer 35

gram negative

Question 36

C. difficile is gram

Answer 36

positive

Question 37

thrush from

Answer 37

candida albicans

Question 38

Polyenes bind to

Answer 38

ergosterol

Question 39

ergosterol is present in

Answer 39

fungal cell wall but not bacterial cell wall

Question 40

amphotericin B

Answer 40

treats serious fungal infections

Question 41

used to treat HIV

Answer 41

saquinavir

Question 42

trimethoprim

Answer 42

treats purine synthesis

Question 43

UTI

Answer 43

nitrofurantoin

Question 44

MRSA treated with

Answer 44

vancomycin

Question 45

nyastatin

Answer 45

fungal infections vagina, oesophageal

Question 46

Azoles function

Answer 46

inhibit ergosterol synthesis

Question 47

azoles treat

Answer 47

yeast infections

Question 48

Aciclovir is an

Answer 48

Anti-herpes drug