Diuretics 4: Osmotic, CA inhibiting & SGLT 2 inhibiting Diuretics Flashcards
1
Q
Example of osmotic diuretic
A
Mannitol
2
Q
Theraputic use of osmotic diuretic
A
- Glaucoma (lowers IOP)
- Lowers Intracerebral pressure
- Acute renal failure
3
Q
Adverse effects of Osmotic diuretics
A
- Expansion of ECM volume —> pulmonary edema
- If taken orally –> Diarrhea
4
Q
Examples of Carbonic Anhydrase inhibiting (CA.I) Diuretics
A
- Acetozolamide
- Dorzolamide
-Zolamide
5
Q
Mechanism of CA.I diuretics
A
- Increases Na+ excretion in PCT
- increases HCO3- excretion in PCT
but self limited, HCO3- will lead to increased NaCL reabsoprtion
6
Q
Theraputic uses of
A
Glaucoma:
* Local drop: open angle
* IV: Closed angle
7
Q
Adverse effect of CA.I Diuretics
A
- Metabolic Acidosis (HCO3- depletion)
- Hypokalemia
- Renal stone formation
8
Q
Example of SGLT2. I diuretics
A
Dapagliflozin
9
Q
Mechanism of SGLT2. I diuretics (dapagliflozin)
A
SGLT2 inhibition –> increase Glucose excretion
10
Q
Theraputic uses of SGLT2. I diuretics (dapagliflozin)
A
- 3rd line therapy for DM
- Heart failure with reduced ejection fraction
11
Q
Adverse effects of SGLT2. I diuretics (dapagliflozin)
A
Urinary tract infections
