Autonomic NS 8: Cholinergic (Nicotinic & Muscarinic) receptors Flashcards
1
Q
Site of Nn Receptors
A
- All autonomic ganglia
- Suprarenal medulla
- CNS
2
Q
site of Nm receptors
A
Motor end plate/neuromuscular junction
3
Q
link between Nn & blood pressure
A
- it’s located in the suprarenal medulla
- it facilitates secretion of catecholamines
- catecholamines increase blood pressure (hypetension)
4
Q
Nn antagonist
A
ganglion blockers
5
Q
Nm antagonist
A
Curare
6
Q
general Sites of Muscarinic receptors
A
- organs supplied by postganglionic parasympathetic
- sweat glands supplied by postganglionic sympthetic
- Blood vessels (causing release of NO and VD)
- CNS
7
Q
M1 receptor mechanism of action
A
Gq ptn
8
Q
M2 receptor mechanism of action
A
Gi ptn
9
Q
M3 receptor mechanism of action
A
Gq
10
Q
site of M1 receptors
A
- CNS
- Parietal cells of stomach releasing HCL
11
Q
site of M2 receptors
A
- CNS
- Heart
- Presynaptic cholinergic fibers
12
Q
site of M3 receptors
A
- CNS
- smooth muscles
- secretory glands
(rest of the body)
13
Q
receptor antagonized by Atropine only
A
M3
14
Q
Antagonists of M1 receptor
A
- Atropine
- Pirenzepine
15
Q
Antagonist of M2 receptor
A
Gallamine
