Autacoids 3: Ergot Alkaloids

Question 1

which receptors do Ergot alkaloids act on

Answer 1

• Alpha Adrenergic receptors
• Dopaminergic receptors
• 5-HT (seretonin) receptors

Question 2

Ergot alkaloids have a very powerful stimulating effect on ____

Answer 2

Uterus

Question 3

Enumerate clinical uses for Ergot Alkaloids

Answer 3

• Migrane
• Hyperprolactinemia
• postpartum hemorrhage

Question 4

ergot Alkaloid used for migrane

Answer 4

Ergotamine

Question 5

ergotamine is combined with ____ to facilitate its absorption

Answer 5

Caffeine

Question 6

Ergot Alkaloids used in Hyperprolactinemia

Answer 6

• Bromocriptine
• Cabergoline (more potent)

Question 7

Which ergot Alkaloid is used in postpartum hemorrhage

Answer 7

Ergometrine (ergonovine)

Question 8

Toxicity & contraindications of ergot alkaloids

Answer 8

• GIT disurbances
• Gangrene (& may require amputation)
• Pregnancy (causes abortion)

Question 9

Infusion of what drug may counteract VC effect of ergot alkaloids

Answer 9

• Nitroglycerin
• Nitroprusside

Vasodilators large doses