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INT 208: Pharmacology > Autonomic NS 1: Adrenergic receptors > Flashcards

Autonomic NS 1: Adrenergic receptors Flashcards

1
Q

Alpha 1 receptor is mainly—–

A

Post-synaptic

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2
Q

Mechanism of Alpha 1 adrenergic receptor

A

facilitate Gq protein as second messenger

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3
Q

Actions of Alpha 1 Adrenergic receptors

A

VC,eyes,hair,stop GIT

  • Generealized Vasoconstriction (Skin, mucous membrane,internal abdominal organs, splanchnic BVs)

Contraction of:
* Dilator pupilae –> pupil dilatation (mydrasis)
* Erector Pile (hair erectors)
* All sphincters of GIT & urinary tract

Relaxation of:
* wall of GIT
+
Facilitates neuromuscular transmission

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4
Q

Alpha 2 receptor is present in—-

A
  • Presynaptic
  • postsynaptic
  • CNS
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5
Q

Mechanism of Alpha 2 receptor

A

facilitate Gi protein as second messenger

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6
Q

Action of Alpha 2 receptor

A
  • Decreases Sympathetic flow from CNS
  • Relaxation of GIT wall (decrease peristalsis)
  • Decrease Insulin secretion
  • Decrease lipolysis
  • Decrease Renin
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7
Q

Both Alpha1 & Alpha2 receptors cause

A
  • Relaxation of wall of GIT
  • Viscid salivary secretion
  • Facilitate neuromuscular transmission
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8
Q

Site of Beta1 Adrenergic receptors

A

Cardiac muscles (mainly)

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9
Q

Mechanism of Beta1 adrenergic receptors

A

facilitate Gs protein as second messenger

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10
Q

Action of Beta1 adrenergic receptors

A
  • Increase all cardiac properites (Contractility, excitability, conductivity, Heart rate)

3aks el Alpha 2:
* stimulate lipolysis (with B3)
* Increase Renin

Increase Aqueous Humour of the eye (with B2)

Relaxation of GIT wall

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11
Q

site of Beta 2 adrenergic receptors

A

mainly in smooth muscles

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12
Q

Mechnism of Beta 2 adrenergic receptors

A

increase cAMP

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13
Q

Action of Beta 2 Adrenrgic receptors

A

EL HOROOB

  • VD to skeletal & Coronary Blood vessels
  • Bronchodilatation

Increase energy, plasma glucose & glucose utilisation:
* increase insulin secretion
* Increase Glycogenolysis
* Increase Lipolysis

Relaxation of:
* GIT wall
* Urinary bladder wall
* Uterus wall

-Muscle tremors

-Increase Intracellular potassium uptake/ decerease extracellular potassium/hypokalemia: to facilitate more muscular contractions

-Increase Aqueous Humour

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14
Q

Mechanism & action of Beta 3 Adrenergic receptors

A

Increase cAMP:
* Increase lipolysis —> increase FFA circulating

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15
Q

Selective Beta 3 Agonist

A

Octopamine

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16
Q

function of Adrenergic presynaptic receptors

A

they are found in CNS and Facilitate Negative feedback (autoreceptors) of NorAdrenaline release

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17
Q

stimulation of presynaptic Alpha 2 Adrenergic receptor leads to

A

Decrease NA release

18
Q

stimulation of presynaptic Beta Adrenergic receptor leads to

A

Increase NA release

19
Q

Adrenergic receptors facilitating generalied VC

A

Alpha 1

20
Q

Adrenergic receptor Facilitating Relaxation of GIT wall

A

(all except Beta3)
* Alpha 1
* Alpha 2
* Beta 1
* Beta 2

21
Q

Which Adenergic receptor facilitates Mydrasis (pupil dilatation)

A

Alpha 1

22
Q

Which Adenergic receptor facilitates Hair erection

A

Alpha 1

23
Q

Which Adenergic receptor facilitates Neuromuscular transmission

A

both Alpha 1 & Alpha 2

24
Q

Which Adenergic receptor results in Viscid Salivary secretion

A

both Alpha 1 & Alpha 2

25
Q

Which Adenergic receptor Decrease Sympathetic Flow from CNS

A

Alpha 2

26
Q

Which Adenergic receptor decreases insulin secretion

A

Alpha 2

27
Q

Which Adenergic receptor decrease Renin

A

Alpha 2

28
Q

Which Adenergic receptor decreases Lipolysis

A

Alpha 2

29
Q

Which Adenergic receptor faciliatates contraction of all GIT & urinary Sphincters

A

Alpha 1

30
Q

Which Adenergic receptor increases all cardiac properties

A

Beta 1

31
Q

Which Adenergic receptor increases Lipolysis

A

all Beta
* Beta 1
* Beta 2
* Beta 3

32
Q

Which Adenergic receptor increases renin

A

Beta 1

33
Q

Which Adenergic receptor increases Aqueous humour formation

A

Beta 1 & Beta 2

34
Q

Which Adenergic receptor facilitates VD of Coronary & skeletal BVs

A

Beta 2

35
Q

Which Adenergic receptor facilitates bronchodilatation

A

Beta 2

36
Q

Which Adenergic receptor increases intracellular uptake of potassium

A

Beta 2 (to increase contraction)

37
Q

Which Adenergic receptor causes relaxation of wall of uterus

A

Beta 2

38
Q

Which Adenergic receptor causes relaxation of urinary bladder

A

Beta 2

39
Q

Which adrenergic receptor increases glycogenolysis & insulin secretion

A

Beta 2

40
Q

Which Adenergic receptor causes muscle tremors

A

Beta 2

INT 208: Pharmacology (30 decks)

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