Autacoids 2: Serotonin (5-HT) Flashcards
1
Q
Serotonin effect on GIT
A
- facilitate peristalsis
- secretion of acetylcholine —> enhance motility
1
Q
Serotonin effect on CVS
A
- Powerful vasoconstriction
- Aggregation of platlets
- Reflex bradycardia
2
Q
effect of Serotonin of NS
A
stimulant for pain, itching, nausea & vomiting
3
Q
Enumerate Serotonin Agonists
A
- Buspirone
- Sumatriptan & Zolmitriptan
- Dexfenfluramine
- Itopride& Cisapride
- Tegaserod
- Escitalopram, fluoxetine, fluvoxamine
4
Q
Action of Buspirone
A
Anxiolytic (effect may take as long as 2 weeks)
Anti-anxiety
5
Q
Action of Sumatriptan & Zolmitriptan
A
- Acute migrane attack treatement (short duration) = VC
6
Q
side effects of Sumatriptan & Zolmitriptan
A
- Tingling
- Dizziness
- neck pain
- Chest pain
7
Q
Contraindications of Sumatriptan & Zolmitriptan
A
- Angina
- Hypertension
- Peripheral vascular disease
- Pregnancy
8
Q
Action of Itopride & Cisapride
A
treatement of GERD
9
Q
Action of Tegaserod
A
treatment of irritable bowel syndrome
10
Q
Action of Escitalopram, fluoxetine, fluvoxamine
A
SSRIs (selective serotonin reuptake inhibitors)
* treatment for psychic depression
11
Q
Enumerate Serotonin Antagonists
A
- Cyproheptadine (also a 1st gen antihistaminic)
- Ketanserin
- Ondansteron, Granisteron
12
Q
uses of Ondansteron, Granisteron
A
CTZ:
* inhibits nausea & vomiting induced by cancer chemotherapy
