[DISCUSSION] MODULE 1 UNIT 3 ADDITIONAL NOTES Flashcards
Increased plasma and serum
IgG
Immunity-conferring function of globulin fraction of the immune system
Immunoglobulins
This makes immunoglobulins the third fastest migrating group of globulin
gamma globulins
Specificity is based on a physical and chemical interaction between the two
V region
Antibody-binding site
Paratope; Fab
Extensive genetic rearrangement (scientist)
Tonegawa
The promotion of phagocytosis of antigens by macrophages and neutrophils is an important factor in
antibacterial defenses
Protein molecules called [?], which can bind the constant region of Ig molecules, are present on the surfaces of macrophages and neutrophils
Fc receptors (FcR)
Binds the fc portion; more efficient
Fc receptors (FcR)
Known opsonin
Phagocytosis
IgG
Natural killer cells
Innate immune system
Kills for the release of GRANZYMES and PERFORINS
Large granulated lymphocytes
can activate a collection of serum glycoproteins called the complement system via the classical pathway
IgM and IgG
Compliment fixation leads to
- Lysis of microbes
- Opsonization and phagocytosis
Lysis of microbes leads to the formation of membrane-activated complex called
Cascade
Enzyme produced during opsonization and phagocytosis
C3 convertase
Two fragments of c3 convertase
C3a
C3b
Known fragment of c3 convertase that will lead to opsonization and phagocytosis with the addition of microbe
C3b
C3, C4, C5
Degradation of basophils and mast cells = HISTAMINE (respiratory inflammatory reactions)
Anaphylatoxins
This is an effector mechanism in which cells coated with antibody react with Fc receptors on natural killer cells (and other lymphocytes) to cause target cell damage
Antibody-Dependent Cell Mediated Cytotoxicity (ADCC)
Binding of AG
Paratope
Site of attack by enzymes
hinge region
Light (L) chains
Number of variable regions
Number of constant regions
Number of domain
1
1
1
Light (L) chains
Number of variable regions
Number of constant regions
Number of domain
1
3
4
seen between:
o heavy chains (H-H)
o heavy chains and light chains (H-L)
Interchain disulfide bonds
Within chains
Holds the domains together
Intrachain disulfide bonds
this shows a wide variation in amino acid sequence in the amino or N terminal portion of the immunoglobulin molecule
Variable (V) Region
