[DISCUSSION] MODULE 1 UNIT 1 Flashcards
Variolation: origin
China
ANCIENT TIMES
- China
- Lady Montagu of Turkey
- Mithridates (Mithridatism)
- Central Africa
- Dutch Guiana
. Venom and ant eggs as treatment for snake bites
- Central Africa
- Dutch Guiana
Djoekas
Contagion
Girolamo Fracastoro (1564)
. Smallpox vaccination
Edward Jenner (1798)
. attenuated chicken cholera, anthrax and rabies vaccines development
Louis Pasteur
. Coined the term vaccine (from the Latin vacca, meaning cows), an honor of Jenner’s work with cowpox inoculation
Louis Pasteur
. blood immunized with staphylococci (weak strains) gives partial protection to the same organism
Richet and Hericourt
. serum of animal immunized with Pseudomonas aeruginosa agglutinated a suspension of the same microbes
Charrin and Rodger
. Specificity of the Protective Effects of Immunization
Pfeiffer
. Discovered the role of leukocytes in phagocytosis
Elie Metchnikoff (1883)
- as part of cellular immunity
INFLAMMATION
. [?]— in animals
Celsus
. [?] — changes occur in CT
Virchow
- local vascular lesion
. Arnold and Cohnheim
action of an immune serum on microbes
Fodor
neutralizing antitoxic activity of sera
Emil von Beh ring and Kitasato (1890)
similar neutralizing activity against snake venom
CaImette
the Pfeiffer phenomenon
Pfeiffer and lssaef
reconciled humoral and cellular theories
Jules Bordet (1895)
Sensitizer and Alexine
Jules Bordet (1895)
. Opsonin
Wright and Douglas
. First to explain the appearance of antibodies in the circulation
Paul Ehrlich — Ehrlich’s Side Chain Theory (1896)
. Key and lock
Paul Ehrlich — Ehrlich’s Side Chain Theory (1896)
Negation to Ehrlichs Theory:
. Bordet
. Arrhenius and Madsen
Father of Immunohematology
Landsteiner (1900)
Haptens
Landsteiner (1900)
Complement Fixation Test
Bordet and Gengou (1901)
Template Theory
Breinl and Haurowitz (1930)
Antibodies are immunoglobulins
Tiselius and Kabat (1939)
. Variable Folding Theory of Antibody Formation
Pauling (1940)
lsoantibody
Bordet
. Anamnesis
Wassermann and von Dugern
bad side of the immune response
Hypersensitivity Studies
. Anaphylaxes
Richet and Portier
Arthus phenomenon
Arthus
. Shwartzman phenomenon
Shwartzman
. serum sickness
Von Pirquet