Diabetes Mellitus Flashcards

1
Q

Diabetes is the ___ leading cause of death in the U.S.

A

7th

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2
Q

How many people in the United States are affected by diabetes?

A

29.1 million

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3
Q

What 3 things is diabetes a leading cause of?

A

adult blindness, end-stage renal disease, non-traumatic lower limb amputations

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4
Q

How much more likely is a person with diabetes to have heart disease or a stroke?

A

2-4 times more likely

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5
Q

What are 3 factors that affect the likelihood of diabetes?

A

Genetic, Autoimmune, Environmental

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6
Q

What are the 4 classes of diabetes?

A

Type I, Type II, Gestational, and Other

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7
Q

How should a diabetic be monitored on a sick day?

A

blood sugar Q4-6H, monitoring ketones

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8
Q

Where is insulin produced?

A

b-cells in islets of Langerhans

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9
Q

How much insulin is secreted by an adult per day?

A

40-50 units

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10
Q

What is a stable blood glucose level?

A

74-106 mg/dL

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11
Q

How long after a meal will insulin concentration peak if there is a normal amount of insulin secretion?

A

1 hour after a meal

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12
Q

What happens if there are high insulin levels?

A

inhibits gluconeogenesis, enhances fat deposition, and increases protein synthesis

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13
Q

What happens when there are low insulin levels?

A

release glucose from liver, protein from muscle, and fat from adipose tissue

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14
Q

Where are insulin receptors normally found?

A

skeletal muscle and adipose tissue

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15
Q

How does insulin function within a cell?

A

“unlocks” receptors so glucose can move into the cell to be used for energy

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16
Q

Which hormones will have a oppose the effects of insulin?

A

glucagon, epinephrine, growth hormone, cortisol

17
Q

What measurements are good indicators of b-cell function and insulin levels?

A

serum and urine c-peptide measurements

18
Q

What percentage of those with diabetes have type 1 diabetes?

19
Q

What is another name for type I diabetes?

A

Insulin-dependent diabetes (requires exogenous insulin)

20
Q

What happens to a person’s body who has type I diabetes?

A

body cells will develop antibodies against insulin and/or pancreatic beta cells that produce the insulin

21
Q

What is latent autoimmune diabetes in adults?

A

slow, progressive type 1 diabetes

22
Q

What can be a result of type I diabetes if it is unknown and there is a rapid onset?

23
Q

A patient comes in complaining of frequent urination, extreme thirst, insatiable hunger accompanied with unintentional weight loss, what may this patient be experiencing?

A

manifestations of Type I diabetes

24
Q

What percentage of those with diabetes have type II diabetes?

25
What are a few risk factors for type II diabetes?
overweight or obese, advanced age, family history
26
Why would someone develop type II diabetes?
Pancreas continues to produce some endogenous insulin but Not enough insulin is produced and/or Body does not use insulin effectively
27
5 ways that type II diabetes may occur
Insulin resistance 2.Decreased insulin production by pancreas 3.Inappropriate hepatic glucose production 4.Altered production of hormones and cytokines by adipose tissue (adipokines) 5.Research continues on role of brain, kidneys, and gut in type 2 diabetes
28
If a patient is presenting with 3 of 5 of the following symptoms: increased glucose levels, abdominal obesity, high BP, high level of triglycerides, and decreased levels of HDLs, what is this patient presenting with?
Metabolic syndrome
29
How is type II diabetes often discovered?
A1C
30
What would be the GTT of someone with prediabetes?
140-199 mg/dL
31
What would the fasting glucose be for a person with prediabetes?
100-125 mg/dL
32
Who is considered high risk for gestational diabetes?
patients that are obese, ama, or have a family history of diabetes
33
When should glucose return to normal levels after the baby is delivered with a mom that had gestational diabetes?
Within 6 weeks postpartum
34
What kind of antibodies are present in type 1 diabetes but absent in type 2 diabetes?
Islet cell antibodies